Prevalence of the Factor XIII Val34Leu Polymorphism in Korean Patients with Deep Vein Thrombosis
| Autor: | Yong-Sung Won, Sang-Seob Yun, In-Sung Moon, Sun Cheol Park, Jeong-Kye Hwang, Ji-Il Kim, Sang Dong Kim, Jang-Sang Park |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Deep vein Single-nucleotide polymorphism 030204 cardiovascular system & hematology Gastroenterology Polymorphism Single Nucleotide White People 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Risk Factors Internal medicine Republic of Korea medicine Humans Genetic Predisposition to Disease cardiovascular diseases Genotyping Allele frequency Genetic Association Studies Venous Thrombosis Fibrin Factor XIII business.industry Incidence Homozygote Case-control study General Medicine Middle Aged Protective Factors medicine.disease Thrombosis Surgery Venous thrombosis medicine.anatomical_structure Phenotype 030228 respiratory system Case-Control Studies Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Annals of vascular surgery. 32 |
| ISSN: | 1615-5947 |
| Popis: | Objective According to recent reports, a common polymorphism resulting in Val to Leu substitution, located 3 amino acids (Val34Leu) upstream of the thrombin cleavage site of FXIII A, has been related to a lower incidence of deep vein thrombosis (DVT). And, a different expression pattern has been shown across nations and races. However, the frequency of FXIII polymorphism expression in Koreans has not been reported in normal individuals or DVT-patient groups. Design Case-control study in Korean population. Methods We investigated the distribution of factor XIII Val34Leu polymorphisms in Korean patients of DVT (50 cases) and Korean healthy controls (100 cases), using real-time polymerase chain reaction for single nucleotide polymorphism genotyping. Results With regard to the frequency of the FXIII polymorphism in DVT patients and in the general control group, all 50 cases in the patient group and 100 cases in the control group were found to be Val34 homozygotes. Conclusions The Val34Leu polymorphism of FXIII was not found in Korean people, and compared with Caucasians, a noticeably low incidence of DVT was shown. Thus, the preventive effect of the Val34 allele of FXIII on the formation of thrombi was shown. |
| Databáze: | OpenAIRE |
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