Genetic profiles of killer-cell immunoglobulin-like receptors and HLA ligands in Thai blood donors
| Autor: | D. Thammanichanond, T. Mongkolsuk, Suwit Chaisri, Chutima Tammakorn, Pimpun Kitpoka, Chanvit Leelayuwat |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Cytotoxicity Immunologic Genotype Immunology chemical and pharmacologic phenomena Blood Donors Human leukocyte antigen Transcriptome 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency Receptors KIR immune system diseases HLA Antigens otorhinolaryngologic diseases Immunology and Allergy Humans Receptor Gene Allele frequency Aged Genetics biology Haplotype hemic and immune systems General Medicine Middle Aged Thailand Killer Cells Natural 030104 developmental biology embryonic structures biology.protein Antibody 030215 immunology |
| Zdroj: | Human immunology. 77(6) |
| ISSN: | 1879-1166 |
| Popis: | Killer-cell immunoglobulin-like receptors (KIRs) play an important role in natural killer (NK) cell regulation. Interaction of KIRs with human leukocyte antigen (HLA) class I molecules can transmit signals to regulate the function of NK cells. In this study, the diversities of KIR genes and their ligands in 500 Thai blood donors were investigated. The coexistence of inhibitory KIRs (iKIR), activating KIRs (aKIR) and their ligands in the same individuals were also analyzed. Overall, 36 KIR genotypes were identified. The most common genotype was genotype AA1 (40.8%). All individuals carried at least one iKIR-HLA pair whereas 18% of the individuals lacked aKIR-HLA pair. The most common compound KIR-HLA profile was the presence of 3 iKIR-HLA pairs with 1 aKIR-HLA pair (21.4%). The most common compound gene profile of KIR-HLA pairs was the combined presence of KIR2DL3-C1, 3DL1-Bw4, 3DL2-A3/A11 and the full length KIR2DS4-its ligands (8%). This study provided a comprehensive analysis of the KIR-HLA profiles in Thai blood donors in regards to KIR genotypes, HLA ligands, KIR-HLA ligand pairs and compound gene profiles of both iKIRs and aKIRs and their ligands. These findings will be useful as baseline information for further studies in the associations of KIR genes and various diseases. |
| Databáze: | OpenAIRE |
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