Cadmium-Induced Testicular Toxicity in Mice: Subacute and Subchronic Route-Dependent Effects
| Autor: | Viviane Gorete Silveira Mouro, Verônica Andrade siman, Fernanda Carolina Ribeiro Dias, Eduardo Medeiros Damasceno, Marli do Carmo Cupertino, Fabiana Cristina Silveira Alves de Melo, Janaina da Silva, Sérgio Luis Pinto da Matta |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Iron Clinical Biochemistry chemistry.chemical_element Administration Oral 010501 environmental sciences Pharmacology medicine.disease_cause 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences Mice Testis medicine Animals Magnesium 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences Cadmium Leydig cell Superoxide Dismutase 030302 biochemistry & molecular biology Biochemistry (medical) Toxicity Tests Subchronic Histology General Medicine Catalase Epithelium Oxidative Stress Zinc Enzyme medicine.anatomical_structure Toxicity Tests Subacute chemistry Apoptosis Calcium Oxidative stress Copper Injections Intraperitoneal |
| Zdroj: | Biological trace element research. 193(2) |
| ISSN: | 1559-0720 |
| Popis: | This study aimed to compare Cd exposure by intraperitoneal (i.p.) and oral routes, evaluating the testicular subacute and subchronic effects. Adult male mice were separated into three groups subdivided according to the experimental period (7 and 42 days after Cd exposure: subacute and subchronic effects, respectively): one group received water and two groups received CdCl2 (1.2 mg/kg i.p. and 24 mg/kg oral). The testicular concentration of essential minerals and Cd, activity of antioxidant enzymes and markers of oxidative stress, histology, and testicular histomorphometry were evaluated. The subacute effect of oral Cd showed reduced Fe concentration, while Ca and Cu increased in this route. The subchronic effect promoted decreasing in Mg in i.p. and oral routes, whereas Zn decreased only in the oral, and the Fe concentration did not change. SOD activity decreased in the oral subacute evaluation and in both pathways, i.p. and oral routes, in the subchronic evaluation, while GST activity increased, and MDA concentration decreased. Labeling of apoptotic cells was increased in the subacute and subchronic evaluation. Seminiferous epithelium degeneration, death of germ cells, and Leydig cell damages occurred in i.p. and oral routes. However, these damages were more intense in the oral route, mainly evaluating the subchronic effects. The results confirm that the severity of Cd-induced testicular injury depends on the pathway, as well as the duration of exposure. |
| Databáze: | OpenAIRE |
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