Gray-matter structure in long-term abstinent methamphetamine users
| Autor: | Binbin Wu, Jing Li, Lili Nie, Tao Ju, Anlian Ren, Wei Luo, Xiantao Wen, Zeyong Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:RC435-571 media_common.quotation_subject Amphetamine-Related Disorders Audiology Methamphetamine Magnet resonance imaging 03 medical and health sciences 0302 clinical medicine Neuroimaging Right hippocampus lcsh:Psychiatry medicine Gray-matter Humans Gray Matter Author Correction media_common Abstinence Volume business.industry Right insula Brain Small sample Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Thickness business Neurocognitive Insula 030217 neurology & neurosurgery Research Article medicine.drug |
| Zdroj: | BMC Psychiatry BMC Psychiatry, Vol 20, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1471-244X |
| DOI: | 10.1186/s12888-020-02567-3 |
| Popis: | Background Previous studies of brain structure in methamphetamine users have yielded inconsistent findings, possibly reflecting small sample size and inconsistencies in duration of methamphetamine abstinence as well as sampling and analyses methods. Here we report on a relatively large sample of abstinent methamphetamine users at various stages of long-term abstinence. Methods Chronic methamphetamine users (n = 99), abstinent from the drug ranging from 12 to 621 days, and healthy controls (n = 86) received T1-weighted structural magnetic resonance imaging brain scans. Subcortical and cortical gray-matter volumes and cortical thickness were measured and the effects of group, duration of abstinence, duration of methamphetamine use and onset age of methamphetamine use were investigated using the Freesurfer software package. Results Methamphetamine users did not differ from controls in gray-matter volumes, except for a cluster in the right lateral occipital cortex where gray-matter volume was smaller, and for regions mainly in the bilateral superior frontal gyrui where thickness was greater. Duration of abstinence correlated positively with gray-matter volumes in whole brain, bilateral accumbens nuclei and insulae clusters, and right hippocampus; and with thickness in a right insula cluster. Duration of methamphetamine use correlated negatively with gray-matter volume and cortical thickness of a cluster in the right lingual and pericalcarine cortex. Conclusions Chronic methamphetamine use induces hard-to-recover cortical thickening in bilateral superior frontal gyri and recoverable volumetric reduction in right hippocampus, bilateral accumbens nuclei and bilateral cortical regions around insulae. These alternations might contribute to methamphetamine-induced neurocognitive disfunctions and reflect a regional specific response of the brain to methamphetamine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink