Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos

Autor: Alexandre Courtiol, Juan A. Amat, Ortaç Onmuş, Frank Cézilly, Mark A. F. Gillingham, Manuel Rendón-Martos, Boudjéma Samraoui, Arnaud Béchet, Simone Sommer
Přispěvatelé: Institute of Evolutionary Ecology and Conservation Genomics, Ulm University, Biogéosciences [Dijon] ( BGS ), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche de la Tour du Valat, Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin Center for Genomics in Biodiversity Research ( BeGenDiv ), Consejería de Medio Ambiente y Ordenación del Territorio, Estación Biológica de Doñana, Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Center of Excellence for Research in Biodiversity, King Saud University [Riyadh] ( KSU ), Laboratoire de Recherche et de Conservation des Zones Humides, Université de Guelma, Department of Biology, Natural History Museum-Ege University, Institut Universitaire de France ( IUF ), Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche ( M.E.N.E.S.R. ), Study funded by the TOTAL foundation, the Conseil Régional de Bourgogne, the MAVA foundation, the Centre National de la Recherche Scientifique (CNRS), and the German Science Foundation (DFG Gi 1065/2-1)., Ege Üniversitesi, Universität Ulm - Ulm University [Ulm, Allemagne], Biogéosciences [UMR 6282] [Dijon] (BGS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Berlin Center for Genomics in Biodiversity Research (BeGenDiv), Estación Biológica de Doñana (EBD), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), King Saud University [Riyadh] (KSU), Ege University-Natural History Museum, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0106 biological sciences
0301 basic medicine
Gene Flow
Genotype
Local adaptation
Population
Genes
MHC Class II
010603 evolutionary biology
01 natural sciences
Intraspecific competition
Gene flow
MHC Genes
Birds
03 medical and health sciences
[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology
environment/Symbiosis
Animals
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
14. Life underwater
Selection
Genetic
education
Ecology
Evolution
Behavior and Systematics
Allelic diversity
MHC genes
Pathogen-mediated balancing selection
Greater flamingos
Alleles
education.field_of_study
Genetic diversity
biology
Histocompatibility Antigens Class II
Genetic Variation
Exons
biology.organism_classification
030104 developmental biology
Evolutionary biology
Biological dispersal
[SDV.IMM]Life Sciences [q-bio]/Immunology
Greater flamingo
Adaptation
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology
environment/Symbiosis
Research Article
Zdroj: BMC Evolutionary Biology
BMC Evolutionary Biology, BioMed Central, 2017, 17 (1), pp.56. 〈https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319168/〉. 〈10.1186/s12862-017-0905-3〉
BMC evolutionary biology, 17:56
BMC Evolutionary Biology, BioMed Central, 2017, 17 (1), pp.56. ⟨10.1186/s12862-017-0905-3⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1471-2148
DOI: 10.1186/s12862-017-0905-3〉
Popis: WOS: 000397335400001
PubMed ID: 28219340
Background: Selective pressure from pathogens is thought to shape the allelic diversity of major histocompatibility complex (MHC) genes in vertebrates. In particular, both local adaptation to pathogens and gene flow are thought to explain a large part of the intraspecific variation observed in MHC allelic diversity. To date, however, evidence that adaptation to locally prevalent pathogens maintains MHC variation is limited to species with limited dispersal and, hence, reduced gene flow. On the one hand high gene flow can disrupt local adaptation in species with high dispersal rates, on the other hand such species are much more likely to experience spatial variation in pathogen pressure, suggesting that there may be intense pathogen mediated selection pressure operating across breeding sites in panmictic species. Such pathogen mediated selection pressure operating across breeding sites should therefore be sufficient to maintain high MHC diversity in high dispersing species in the absence of local adaptation mechanisms. We used the Greater Flamingo, Phoenicopterus roseus, a long-lived colonial bird showing a homogeneous genetic structure of neutral markers at the scale of the Mediterranean region, to test the prediction that higher MHC allelic diversity with no population structure should occur in large panmictic populations of long-distance dispersing birds than in other resident species. Results: We assessed the level of allelic diversity at the MHC Class IIB exon 2 from 116 individuals born in four different breeding colonies of Greater Flamingo in the Mediterranean region. We found one of the highest allelic diversity ( 109 alleles, 2 loci) of any non-passerine avian species investigated so far relative to the number of individuals and loci genotyped. There was no evidence of population structure between the four major Mediterranean breeding colonies. Conclusion: Our results suggest that local adaptation at MHC Class IIB in Greater Flamingos is constrained by high gene flow and high MHC diversity appears to be maintained by population wide pathogen-mediated selection rather than local pathogen-mediated selection. Further understanding of how pathogens vary across space and time will be crucial to further elucidate the mechanisms maintaining MHC diversity in species with large panmictic populations and high dispersal rates.
TOTAL foundation; Conseil Regional de BourgogneRegion Bourgogne-Franche-Comte; MAVA foundation; Centre National de la Recherche Scientifique (CNRS)Centre National de la Recherche Scientifique (CNRS); German Science FoundationGerman Research Foundation (DFG) [DFG Gl 1065/2- 1]
This study was funded by the TOTAL foundation, the Conseil Regional de Bourgogne, the MAVA foundation, the Centre National de la Recherche Scientifique (CNRS), and the German Science Foundation (DFG Gl 1065/2- 1).
Databáze: OpenAIRE
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