Effects of nutritional status on serum fetuin-A level
| Autor: | Hilal Yildiran, Mehmet Arif Icer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
alpha-2-HS-Glycoprotein 030309 nutrition & dietetics Nutritional Status Disease Industrial and Manufacturing Engineering 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Internal medicine Diabetes mellitus medicine Extracellular Humans Obesity Noncommunicable Diseases 0303 health sciences business.industry Fatty liver Nutrients 04 agricultural and veterinary sciences General Medicine medicine.disease 040401 food science Fetuin Diet Endocrinology chemistry Chronic Disease Curcumin business Niacin Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 60:1938-1946 |
| ISSN: | 1549-7852 1040-8398 |
| DOI: | 10.1080/10408398.2019.1631751 |
| Popis: | Fetuin-A is a glycoprotein structured molecule which is mostly released by the liver. As a multifunctional protein, fetuin-A has positive effects on health such as calcification, cardiovascular diseases and tumor development processes with various mechanisms, whereas it plays a negative role in the processes of obesity, diabetes and fatty liver disease. There are a large number of studies reporting that serum fetuin-A levels are affected by several dietary factors. It is reported in some of these studies that several nutrients increase fetuin-A release, while some others have adverse effects. It is put forward that some nutrients such as dairy products, curcumin, niacin, palmitate, coffee and alcohol consumption decrease fetuin-A level, and dietary omega-3 fatty acids intake may increase fetuin-A concentration. In addition, it is indicated that high blood glucose levels increase hepatic fetuin-A release by activating extracellular signal-regulated kinase 1/2 enzymes and increased plasma free fatty acids do the same effect by increasing NF-B-K activity. Despite these studies in the literature, there is not any review evaluating fetuin-A, chronic diseases and nutrition together. Therefore, in this study, the relationship between serum fetuin levels and some diseases and the effects of nutrients on fetuin A levels were investigated with possible mechanisms. |
| Databáze: | OpenAIRE |
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