Pyrrolidinyl Peptide Nucleic Acid Homologues: Effect of Ring Size on Hybridization Properties
| Autor: | Woraluk Mansawat, Tirayut Vilaivan, Árpád Balázs, David J. Aitken, Chotima Vilaivan |
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| Rok vydání: | 2012 |
| Předmět: |
Peptide Nucleic Acids
Base Sequence Molecular Structure Peptide nucleic acid Organic Chemistry Nucleic Acid Hybridization RNA DNA Biochemistry Cyclobutane Ring size chemistry.chemical_compound Nucleic acid thermodynamics Peptide backbone chemistry Complementary DNA Molecule Physical and Theoretical Chemistry Cyclobutanes |
| Zdroj: | Organic Letters. 14:1440-1443 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol300190u |
| Popis: | The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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