Limited comparability of creatinine assays in patients with liver cirrhosis and their impact on the MELD score
| Autor: | Ralf Lichtinghagen, Thorsten Kaiser, Korbinian Brand, Michael Kiehntopf, Diana Karailieva, Christina Ritter-Sket, Anja Kessler, Carsten Gnewuch, Benedict Kinny-Köster, Michael Schmidt, Joachim Thiery |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Cirrhosis Bilirubin medicine.medical_treatment Clinical Biochemistry 030230 surgery Liver transplantation Gastroenterology Article lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound Liver disease 0302 clinical medicine Internal medicine Medicine In patient Creatinine lcsh:R5-920 Radiological and Ultrasound Technology business.industry medicine.disease Serum samples chemistry Reference measurement lcsh:QD1-999 030211 gastroenterology & hepatology business lcsh:Medicine (General) |
| Zdroj: | Practical Laboratory Medicine Practical Laboratory Medicine, Vol 8, Iss, Pp 41-48 (2017) |
| ISSN: | 2352-5517 |
| Popis: | Background & aim: Patients with end-stage liver disease require valid estimations of mortality for organ allocation and risk stratification. The model of end-stage liver disease (MELD) score is used for this purpose in most countries and incorporates bilirubin, International Normalized ratio, and creatinine. The aim of this study was to evaluate the comparability of creatinine results from different routine assays in the serum samples of patients with liver cirrhosis. Methods: Residual material from 60 serum samples was available from patients in different stages of liver cirrhosis. Four centers participated; each center analyzed the samples with Jaffé-based and enzymatic routine assays in parallel. In addition, an accredited calibration laboratory certified the panel of samples by an internationally accepted reference measurement procedure (RMP) based on isotope dilution mass spectrometry (ID-MS). This method served as the independent reference. Results: All routine methods displayed a high correlation to the RMP (r ≥0.937, p20% in up to 27% of the samples. The enzymatic methods were systematically lower, whereas the Jaffé-based methods were systematically higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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