Relationship between infarct size and serum uric acid levels during the acute phase of stroke

Autor: Ramón Rodrigo, Rodrigo Fernández-Gajardo, Gabriel Cavada, Juan A. Pasten, José Manuel Matamala, Walter Feuerhake, Gonzalo Bustamante, Pablo Reyes, Camilo G. Sotomayor, Rodrigo Gutiérrez, Prudencio Lozano, Ignacio A. Cortés-Fuentes, Rodrigo Guerrero, Gabriel Andrés Rodríguez Vargas
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Antioxidant
medicine.medical_treatment
030204 cardiovascular system & hematology
Fluid-attenuated inversion recovery
Vascular Medicine
Biochemistry
Antioxidants
Diagnostic Radiology
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
Stroke
Brain Mapping
Microscopy
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Statistics
Light Microscopy
Thrombolysis
Middle Aged
Magnetic Resonance Imaging
Pathophysiology
Chemistry
Neurology
Physical Sciences
Cardiology
Regression Analysis
Medicine
Female
Research Article
medicine.medical_specialty
Imaging Techniques
Fluorescence Recovery after Photobleaching
Cerebrovascular Diseases
Brain Morphometry
Science
Neuroimaging
Linear Regression Analysis
Research and Analysis Methods
Neuroprotection
03 medical and health sciences
Diagnostic Medicine
Internal medicine
medicine
Humans
cardiovascular diseases
Statistical Methods
Ischemic Stroke
business.industry
Diffusion Weighted Imaging
Chemical Compounds
Biology and Life Sciences
Magnetic resonance imaging
medicine.disease
Uric Acid
chemistry
Linear Models
Uric acid
business
Acids
030217 neurology & neurosurgery
Mathematics
Neuroscience
Zdroj: PLoS ONE, Vol 14, Iss 7, p e0219402 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: IntroductionUric acid has gained considerable attention as a potential neuroprotective agent in stroke during the last decades, however, its role in the pathophysiology of ischemic stroke remains poorly understood. A serial evaluation of uric acid levels during the acute phase of stroke and its association with infarct size on magnetic resonance imaging is lacking.MethodsWe present a cohort study of 31 patients with ischemic stroke who were not candidates for thrombolysis according to current criteria at the time. We performed daily measurements of serum uric acid and total antioxidant capacity of plasma during the first week after symptoms onset and 30 days after. Infarct size was determined in the acute phase by a DWI sequence and the final infarct size with a control MRI (FLAIR) at day 30.ResultsUric acid significantly decreases between days 2 to 6 compared to day 1, after adjustment by sex, age and DWI at diagnosis, with a nadir value at 72h. A mixed model analysis showed a negative association between DWI at diagnosis and uric acid evolution during the first week after stroke. Moreover, multivariable linear regression of uric acid values during follow up on DWI volumes demonstrated that DWI volume at diagnosis is negatively associated with uric acid levels at day 3 and 4. There were no significant associations between total antioxidant capacity of plasma and DWI at diagnosis, or FLAIR at any point.DiscussionPatients with larger infarcts exhibited a significant decrease in serum uric acid levels, accounting for a more prominent reactive oxygen species scavenging activity with subsequent consumption and decay of this antioxidant. The different kinetics of total antioxidant capacity of plasma and serum uric acid levels suggests a specific role of uric acid in the antioxidant response in ischemic stroke.
Databáze: OpenAIRE
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