HIV-Induced CPSF6 Condensates

Autor: Selen Ay, Francesca Di Nunzio
Přispěvatelé: Virologie Moléculaire Avancée / Advanced Molecular Virology (VMA), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), F.D.N. is supported by the Institut Pasteur and ANRS grants (ECTZ192036, ECTZ137593) and Sidaction grant. S.A. is supported by the ANRS fellowship ECTZ204694.
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Molecular Biology
Journal of Molecular Biology, 2023, pp.168094. ⟨10.1016/j.jmb.2023.168094⟩
ISSN: 0022-2836
1089-8638
DOI: 10.1016/j.jmb.2023.168094⟩
Popis: International audience; Viruses are obligate parasites that rely on their host's cellular machinery for replication. To facilitate their replication cycle, many viruses have been shown to remodel the cellular architecture by inducing the formation of membraneless organelles (MLOs). Eukaryotic cells have evolved MLOs that are highly dynamic, self-organizing microenvironments that segregate biological processes and increase the efficiency of reactions by concentrating enzymes and substrates. In the context of viral infections, MLOs can be utilized by viruses to complete their replication cycle. This review focuses on the pathway used by the HIV-1 virus to remodel the nuclear landscape of its host, creating viral/host niches that enable efficient viral replication. Specifically, we discuss how the interaction between the HIV-1 capsid and the cellular factor CPSF6 triggers the formation of nuclear MLOs that support nuclear reverse transcription and viral integration in favored regions of the host chromatin. This review compiles current knowledge on the origin of nuclear HIV-MLOs and their role in early post-nuclear entry steps of the HIV-1 replication cycle.
Databáze: OpenAIRE
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