Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis
| Autor: | Timothy Hla, Claire V. Kent, Xi Kathy Zhou, Kotha Subbaramaiah, Sung Hee Chang, Per-Johan Jakobsson, Andrew J. Dannenberg, Louise R. Howe, Clifford A. Hudis |
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| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
musculoskeletal diseases Genetically modified mouse Carcinogenesis Receptor ErbB-2 Physiology Angiogenesis Prostaglandin Mice Transgenic Biology medicine.disease_cause Biochemistry Article Mice chemistry.chemical_compound Aromatase Mammary Glands Animal Cell Line Tumor medicine Animals Humans Gene knockout Cell Proliferation Prostaglandin-E Synthases Pharmacology Mammary tumor Neovascularization Pathologic Mammary Neoplasms Experimental Cancer Cell Biology medicine.disease Gene Expression Regulation Neoplastic Intramolecular Oxidoreductases chemistry Microvessels Cancer research biology.protein Female lipids (amino acids peptides and proteins) Gene Deletion |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 106:99-105 |
| ISSN: | 1098-8823 |
| DOI: | 10.1016/j.prostaglandins.2013.04.002 |
| Popis: | The cyclooxygenase/prostaglandin (COX/PG) signaling pathway is of central importance in inflammation and neoplasia. COX inhibitors are widely used for analgesia and also have demonstrated activity for cancer prophylaxis. However, cardiovascular toxicity associated with this drug class diminishes their clinical utility and motivates the development of safer approaches both for pain relief and cancer prevention. The terminal synthase microsomal PGE synthase-1 (mPGES-1) has attracted considerable attention as a potential target. Overexpression of mPGES-1 has been observed in both colorectal and breast cancers, and gene knockout and overexpression approaches have established a role for mPGES-1 in gastrointestinal carcinogenesis. Here we evaluate the contribution of mPGES-1 to mammary tumorigenesis using a gene knockout approach. Mice deficient in mPGES-1 were crossed with a strain in which breast cancer is driven by overexpression of human epidermal growth factor receptor 2 ( HER2/neu ). Loss of mPGES-1 was associated with a substantial reduction in intramammary PGE 2 levels, aromatase activity, and angiogenesis in mammary glands from HER2/neu transgenic mice. Consistent with these findings, we observed a significant reduction in multiplicity of tumors ≥1 mm in diameter, suggesting that mPGES-1 contributes to mammary tumor growth. Our data identify mPGES-1 as a potential anti-breast cancer target. |
| Databáze: | OpenAIRE |
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