Respiratory viruses detected in Mexican children younger than 5 years old with community-acquired pneumonia: a national multicenter study

Autor: Enrique R. Ortiz-García, Carmen Soria-Rodríguez, Daniel E. Noyola, José Ignacio Santos-Preciado, Luis Fernando Perez Gonzalez, Alejandra Pamela Gonzalez-Rodriguez, Navarrete-Navarro S, Teresa Hernández-Andrade, Jesus Gaitan Meza, Eneida Sánchez-Medina, Alberto Vilaseñor-Sierra, Verónica Firo-Reyes, Celia Alpuche-Aranda, Adoniram Carrasco-Castillo, Victor Hugo Rivera-Nuñez, Miguel L. García-León, Irma López-Martínez, Gerardo Martínez-Aguilar, Rosa María Wong-Chew, Carlos N. Del Río-Almendarez, Oscar Newton-Sánchez
Rok vydání: 2016
Předmět:
0301 basic medicine
Rhinovirus
viruses
medicine.disease_cause
0302 clinical medicine
Community-acquired pneumonia
Risk Factors
Medicine
Metapneumovirus
030212 general & internal medicine
Respiratory Tract Infections
Children
Cause of death
Coronavirus
Enterovirus
Coinfection
General Medicine
Community-Acquired Infections
Infectious Diseases
Child
Preschool
Viruses
Female
Seasons
Microbiology (medical)
medicine.medical_specialty
030106 microbiology
Pneumonia
Viral
Virus
Article
lcsh:Infectious and parasitic diseases
Adenoviridae
03 medical and health sciences
Internal medicine
Humans
lcsh:RC109-216
Mexico
Demography
Retrospective Studies
Respiratory viruses
business.industry
Infant
Pneumonia
medicine.disease
Cross-Sectional Studies
Respiratory Syncytial Virus
Human
Immunology
Etiology
business
Zdroj: International Journal of Infectious Diseases
International Journal of Infectious Diseases, Vol 62, Iss C, Pp 32-38 (2017)
ISSN: 1878-3511
Popis: Background Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old. Methods One thousand four hundred and four children younger than 5 years of age with a clinical and/or radiological diagnosis of CAP in 11 hospitals in Mexico were included. Nasal washes were collected, placed in viral medium, and frozen at −70°C until processing. The first 832 samples were processed using the multiplex Bio‐Plex/Luminex system and the remaining 572 samples using the Anyplex multiplex RT-PCR. Clinical data regarding diagnosis, clinical signs and symptoms, radiographic pattern, and risk factors were obtained and recorded. Results Of the samples tested, 81.6% were positive for viruses. Respiratory syncytial virus (types A and B) was found in 23.7%, human enterovirus/rhinovirus in 16.6%, metapneumovirus in 5.7%, parainfluenza virus (types 1–4) in 5.5%, influenza virus (types A and B) in 3.6%, adenovirus in 2.2%, coronavirus (NL63, OC43, 229E, and HKU1) in 2.2%, and bocavirus in 0.4%. Co-infection with two or more viruses was present in 22.1%; 18.4% of the samples were negative. Using biomass for cooking, daycare attendance, absence of breastfeeding, and co-infections were found to be statistically significant risk factors for the presence of severe pneumonia. Conclusions Respiratory syncytial virus (types A and B), human enterovirus/rhinovirus, and metapneumovirus were the respiratory viruses identified most frequently in children younger than 5 years old with CAP. Co-infection was present in an important proportion of the children.
Databáze: OpenAIRE
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