High levels of FSH before puberty are associated with increased risk of metabolic syndrome during pubertal transition

Autor:	Banu Kucukemre Aydin, Rasmus Stenlid, Iris Ciba, Sara Y. Cerenius, Marie Dahlbom, Peter Bergsten, Ricard Nergårdh, Anders Forslund
Rok vydání:	2022
Předmět:	Male Metabolic Syndrome obesity Cancer och onkologi Pediatric Obesity Nutrition and Dietetics sex hormone binding globulin (SHBG) Health Policy Puberty Public Health Environmental and Occupational Health Pediatrik Pediatrics metabolic syndrome Body Mass Index insulin resistance Cancer and Oncology Pediatrics Perinatology and Child Health Humans Female follicle-stimulating hormone (FSH) Longitudinal Studies Follicle Stimulating Hormone Insulin Resistance Child
Zdroj:	Pediatric obesity. 17(8)
ISSN:	2047-6310
Popis:	Background During perimenopause, the rise in serum follicle-stimulating hormone (FSH) is associated with increased adiposity, insulin resistance (IR), and metabolic syndrome (MetS). However, data for the pubertal period, which is characterized by increasing FSH levels and changing body composition, are limited. Objectives To investigate the relationships between FSH and anthropometric changes, IR markers, and development of MetS in the peripubertal period. Methods Uppsala Longitudinal Study of Childhood Obesity (ULSCO) is an ongoing study that aims to understand the factors contributing to childhood obesity and the development of obesity-related diseases. We analysed the subset of participants who were prepubertal at the first visit (n = 95, 77 with obesity). Mean follow-up time was 3.0 +/- 1.4 years. Results Higher serum FSH levels at the first visit were associated with an increased likelihood of elevation in body mass index (BMI SDS) (p = 0.025, OR = 16.10) and having MetS (p = 0.044, OR = 4.67) at the follow-up. We observed nonlinear relationships between varying serum FSH levels and markers of adiposity and IR, especially in girls. At the first visit, when girls were prepubertal, FSH was negatively associated with BMI (beta = -0.491, p = 0.005) and positively associated with sex hormone-binding globulin (SHBG) (beta = 0.625, p = 0.002). With the progression of puberty, negative associations between BMI and SHBG disappeared while FSH became positively associated with HOMA-IR (beta = 0.678, p = 0.025) and fasting insulin (beta = 0.668, p = 0.027). Conclusions Higher serum FSH levels in prepubertal children were associated with an increased risk of MetS development during pubertal transition. Along with nonlinear associations between varying serum FSH levels and IR markers, our results might imply a relationship between FSH and IR of puberty.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9923b390800613151082685beaf727ac https://pubmed.ncbi.nlm.nih.gov/35226970 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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