Premedication with diclofenac and precurarization with atracurium on succinylcholine-induced myalgia in laparoscopic cholecystectomy: A double-blinded randomized study

Autor: Amit, Tirkey, Mukesh, Kumar, Ekramul, Haque, Tushar, Kumar, Ladhu, Lakra, Usha, Suwalka
Rok vydání: 2022
Předmět:
Zdroj: Anesthesia: Essays and Researches. 16:89
ISSN: 0259-1162
DOI: 10.4103/aer.aer_35_22
Popis: Succinylcholine is the only available depolarizing neuromuscular blocker that has been widely used in the induction of anesthesia, and it is the drug of choice for rapid-sequence induction of anesthesia due to its rapid onset of effect and ultrashort duration of action owing to its rapid hydrolysis by acetyl-cholinesterase. Postoperative muscle pain (myalgia) and muscle stiffness are the most common side effects and are observed most frequently on the 1It is a double-blind randomized comparative study carried out in a tertiary care hospital. The study sample was 60 and divided into two equal groups. All data entered in MS-Excel Sheet and Wilcoxon signed-rank test were done for nonparametric data and one-way ANOVA for the parametric data. The normal distribution of the study sample was tested by the Shapiro - Wilk test.The fasciculations in the test group were much less than in the control group withSuccinylcholine-induced myalgia has a complex pathophysiology. However, the preemptive use of diclofenac in combination with precurarization can alleviate the incidence and severity of succinylcholine-induced myalgia. Therefore, its use may be considered in routine cases for induction of anesthesia for facilitating laryngoscopy and endotracheal intubation.
Databáze: OpenAIRE
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