Production of eicosapentaenoic acid by high cell density cultivation of the marine oleaginous diatom Fistulifera solaris
| Autor: | Daisuke Nojima, Yoshiaki Maeda, Takashi Yabuuchi, Mitsufumi Matsumoto, Tomoko Yoshino, Tsuyoshi Tanaka |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine Environmental Engineering Biomass Fistulifera solaris Bioengineering Cell Count Biology 01 natural sciences 03 medical and health sciences Aquaculture 010608 biotechnology Microalgae Production (economics) Humans Food science Waste Management and Disposal chemistry.chemical_classification Diatoms Renewable Energy Sustainability and the Environment business.industry General Medicine biology.organism_classification Eicosapentaenoic acid Biotechnology 030104 developmental biology Diatom chemistry Productivity (ecology) Eicosapentaenoic Acid Fatty Acids Unsaturated lipids (amino acids peptides and proteins) business Polyunsaturated fatty acid |
| Zdroj: | Bioresource technology. 245 |
| ISSN: | 1873-2976 |
| Popis: | Polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA), have attracted attention owing to their health benefits for humans, as well as their importance in aquaculture and animal husbandry. Establishing a sustainable PUFA supply based on fish oils has been difficult due to their increasing demand. Therefore, alternative sources of PUFAs are required. In this research, we examined the potential of the marine oleaginous diatom Fistulifera solaris as an alternative producer of PUFAs. Optimization of culture conditions was carried out for high cell density cultivation, and a maximal biomass productivity of 1.32±0.13g/(L·day) was achieved. By slightly adjusting the culture conditions for EPA production, the maximal EPA productivity reached 135.7±10.0mg/(L·day). To the best of our knowledge, this is the highest EPA productivity among microalgae cultured under photoautotrophic conditions. This result indicates that F. solaris is a promising candidate host for sustainable PUFA production. |
| Databáze: | OpenAIRE |
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