Leptina, Elo Adicional na Fisiopatologia da Pré-eclâmpsia?
| Autor: | Emilio Antonio Francischetti, S.G. Barroso, A.V.B. Duarte, Virgínia Genelhu de Abreu |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Índice de massa corporal
medicine.medical_specialty Pregnancy Proteinuria business.industry Leptin Obstetrics and Gynecology Radioimmunoassay Gynecology and obstetrics medicine.disease lcsh:Gynecology and obstetrics Preeclampsia Endocrinology Blood pressure Leptina Internal medicine Complicações da gravidez RG1-991 Gestation Medicine Hipertensão arterial medicine.symptom business Body mass index lcsh:RG1-991 |
| Zdroj: | Revista Brasileira de Ginecologia e Obstetrícia, Vol 23, Iss 5, Pp 283-287 (2001) Revista Brasileira de Ginecologia e Obstetrícia v.23 n.5 2001 Revista brasileira de ginecologia e obstetrícia Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO |
| ISSN: | 0100-7203 |
| DOI: | 10.1590/s0100-72032001000500003 |
| Popis: | Purpose: to study in primigravid adolescents the behavior of serum leptin levels during the evolution of normal pregnancy, comparing the results with those obtained from preeclamptics. Methods: prospective, longitudinal study conducted in 15 normotensive pregnant adolescents and 5 preeclamptic adolescents. Serum leptin levels (ng/mL) were determined by radioimmunoassay. Blood pressure was measured by the oscilometric method by using DINAMAP 1846. Patients were evaluated in two different gestational periods: between the 21st and 30th week and between the 31st and 40th week. The ratio leptin/body mass index (BMI) was used to correct changes observed in BMI throughout gestation. Preeclamptic pregnant patients were diagnosed when the blood pressure was ³140/90 mmHg, proteinuria >300 mg/24 h and when arteriolar spasm was present in the optic fundi. Results: there was a trend towards an elevation of serum leptin at the end of pregnancy in both groups although more pronounced in preeclamptic patients. In pregnant normotensive patients serum leptin increased from 11.9±1.20 (21st to 30th week) to 13.9±2.23 ng/mL (31st to 40th week), and in preeclamptic from 11.9±1.20 to 17.6±4.565 ng/mL. In preeclamptic patients the BMI increased significantly in the period from the 21st to 30th week when compared to the period between the 31st and 40th week: 21.5±0.8 vs 27.4±1.7 kg/m2, p |
| Databáze: | OpenAIRE |
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