Prognostic significance of soluble forms of immune checkpoint PD-1/PDL1 receptor and ligand in blood plasma of gastric cancer patients
| Autor: | N. E. Kushlinskii, N.A. Ognerubov, N Yu Sokolov, A A Alferov, E S Gershtein, E A Korotkova, E I Karamysheva, Ivan Stilidi, M M Kontorshchikov, V L Chang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Programmed Cell Death 1 Receptor Disease Treatment results Ligands Gastroenterology 03 medical and health sciences Plasma 0302 clinical medicine Stomach Neoplasms Internal medicine Blood plasma Biomarkers Tumor Medicine Humans Stage (cooking) Receptor business.industry Biochemistry (medical) Cancer General Medicine medicine.disease Ligand (biochemistry) Prognosis Immune checkpoint Medical Laboratory Technology 030220 oncology & carcinogenesis business 030215 immunology |
| Zdroj: | Klinicheskaia laboratornaia diagnostika. 66(3) |
| ISSN: | 0869-2084 |
| Popis: | Analysis of long-term treatment results of 101 primary gastric cancer patients at various stages of the tumor process followed during 1 - 41 months (median - 6,4 months) from the onset of specific treatment are presented depending on the levels of soluble forms (s) of PD-1 receptor and its ligand PD-L1 in blood plasma. Overall survival assessed by Kaplan-Meyer analysis and with the help of Cox multiparametric regression model was applied as the criterion of prognostic value. It was found that at high (≥ 35 pg/ml) sPD-L1 levels in blood plasma, the overall survival of patients with gastric cancer was statistically significantly lower than at the marker’s levels below 35 pg / ml (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|