Mechanistic Study ofα-Amino AcidN-Carboxyanhydride (NCA) Polymerization by Capillary Electrophoresis
| Autor: | François Schué, Willy Vayaboury, Olivia Giani, Hervé Cottet, Séverine Bonaric |
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| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Organisation moléculaire (évolution et matériaux fluores) (OMEMF), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
Polymers and Plastics
Chemistry Organic Chemistry Size-exclusion chromatography capillary electrophoresis • living polymerization • nonaqueous polypeptides • temperature decrease • urea Solution polymerization 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Ring-opening polymerization 0104 chemical sciences chemistry.chemical_compound [CHIM.POLY]Chemical Sciences/Polymers Capillary electrophoresis Polymerization Hexylamine Polymer chemistry Materials Chemistry Living polymerization Molar mass distribution Physical and Theoretical Chemistry 0210 nano-technology |
| Zdroj: | Macromolecular Chemistry and Physics Macromolecular Chemistry and Physics, Wiley-VCH Verlag, 2008, 209 (15), pp.1628-1637. ⟨10.1002/macp.200800096⟩ |
| ISSN: | 1521-3935 1022-1352 |
| Popis: | International audience; Polymerizations of N-trifluoroacetyl-L-lysine N-carboxyanhydride initiated by hexylamine were performed in N,N-dimethylformamide with different monomer to initiator ratios and at different temperatures. Poly(N-trifluoroacetyl-L-lysine) samples were characterized by size exclusion chromatography coupled with multi-angle laser light detection (SEC-MALLS) and capillary electrophoresis (CE). If SEC-MALLS analysis emphasizes the double distribution in molecular weight, nonaqueous CE (NACE) brings additional quantitative information on the oligomeric distribution and on the distribution according to polymer functionality (end-groups). At room temperature, two termination reactions were clearly identified for these polymerizations. The suppression of these side reactions is reported upon decreasing the reaction temperature to 0 °C. A strong reduction of the bimodal aspect of the molecular weight distribution was obtained with the addition of urea to the polymerization medium. The possibility of a living and controlled polymerization at 0 °C with urea was demonstrated and illustrated by the synthesis of two block copolypeptides. |
| Databáze: | OpenAIRE |
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