Multiple effects of arginine vasopressin on prostaglandin E2 synthesis in fibroblasts
| Autor: | Grossman Nili, Danon Abraham, Kagan Elena, Fleisher-Berkovich Sigal |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Prostaglandin E2 receptor Prostaglandin Neuropeptide Biology Dinoprostone chemistry.chemical_compound Arginine vasopressin receptor 2 Internal medicine medicine Humans Prostaglandin E2 Cells Cultured Pharmacology Arginine vasopressin receptor 1B Dose-Response Relationship Drug Fibroblasts Arginine Vasopressin Endocrinology chemistry Eicosanoid hormones hormone substitutes and hormone antagonists medicine.drug Interleukin-1 |
| Zdroj: | European journal of pharmacology. 485(1-3) |
| ISSN: | 0014-2999 |
| Popis: | Recent evidence supports the viewpoint that vasopressin, a neurohypophyseal peptide, should be also considered as a neuroendocrine modulator of immune and inflammatory responses. In this work we investigated the role of vasopressin in the regulation of prostaglandin E(2) synthesis by human dermal fibroblasts. Recombinant human interleukin-1 beta increased prostaglandin E(2) synthesis in fibroblasts about sixfold. The prostaglandin E(2) response to interleukin-1 beta was attenuated by lower concentrations of vasopressin (10(-10)-10(-9) M). By contrast, higher concentrations (10(-8)-10(-7) M) of vasopressin effected significant enhancement of the interleukin-1 beta-induced prostaglandin E(2) synthesis. In a similar way, vasopressin (10(-8)-10(-7) M), in the absence of interleukin-1, significantly increased prostaglandin E(2) production. An inhibitory effect of lower concentrations of vasopressin was also observed on basal production of prostaglandin E(2). The effects of vasopressin on basal and interleukin-1 beta-induced prostaglandin E(2) synthesis were antagonized by selective vasopressin receptor antagonists. The findings presented here disclose a novel modulatory role of vasopressin on prostaglandin E(2) synthesis in human dermal fibroblasts and suggest a possible role of vasopressin in the regulation of inflammation. |
| Databáze: | OpenAIRE |
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