Perioperative Predictors of Survival After Liver Transplantation for Familial Amyloid Polyneuropathy in a Portuguese Center
| Autor: | I. Aragão, João Marcelo Robazzi Bignelli Valente Aguiar, Z. Moreira, S. Esteves, B. Gomes, F. Lagarto, Luiz Carlos de Alcântara Fonseca, J. Daniel, T. Branco, P. Sá Couto, H.P. Miranda, F. Correia de Barros |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis medicine.medical_treatment Operative Time Kaplan-Meier Estimate Liver transplantation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Survival rate Retrospective Studies Amyloid Neuropathies Familial Transplantation Portugal business.industry Retrospective cohort study Patient survival Perioperative Middle Aged Liver Transplantation Surgery Survival Rate Multivariate Analysis Disease Progression Amyloid polyneuropathy Female 030211 gastroenterology & hepatology business Body mass index 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Transplantation Proceedings. 48:2098-2101 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2016.04.020 |
| Popis: | Background Liver transplantation (LT) has been the treatment of choice to halt the progression of familial amyloid polyneuropathy (FAP). Few studies have identified prognostic factors for post-LT survival in FAP. Our aim was to assess survival rate and to identify independent factors for survival after LT. Methods This retrospective cohort study of FAP patients transplanted for the first time analyzed 116 transplantations from 2006 to 2014. The median follow-up period was 45.5 months. Results The overall survival rates at 1 month, 1 year, and 5 years were 89%, 82% and 79%, respectively. On multivariate analysis, only number of red blood cell (RBC) units transfused during surgery, operation time, and body mass index were independent prognostic factors for patient survival. Only 30% of patients were transfused during surgery, and, in these, each RBC unit transfused increased mortality by 53%. The operation time increased mortality by 20% for every 15 minutes of surgery. Conclusions This study suggests that operation time and RBC transfused are predominant factors affecting post-LT survival in our FAP patients. |
| Databáze: | OpenAIRE |
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