Effects of the 5-HT1A receptor agonists buspirone and 8-OH-DPAT on pupil size in common marmosets
| Autor: | Manato Kotani, Kazuhito Ikeda, Naoko Urushino, Itaru Natsutani, Yuji Ogi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Miosis genetic structures Infrared Rays Pyridines medicine.drug_class Pharmacology Piperazines Pupil Buspirone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Mydriasis Pupillary response Animals 8-Hydroxy-2-(di-n-propylamino)tetralin Dose-Response Relationship Drug business.industry 8-OH-DPAT Callithrix Serotonin 5-HT1 Receptor Agonists Receptor antagonist eye diseases Psychiatry and Mental health 030104 developmental biology chemistry 5-HT1A receptor Female sense organs medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural Pharmacology. 28:313-317 |
| ISSN: | 0955-8810 |
| Popis: | As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). Thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. Common marmosets have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field because of handling ease compared with other nonhuman primates and the requirement for small amounts of test drugs. In this study, we constructed a system for measuring changes in pupil size using an infrared eye-tracking camera and evaluated the effects on pupil size of the 5-HT1A receptor agonists buspirone, 8-OH-DPAT and buspirone active metabolite 1-(2-pyrimidinyl) piperazine. Our results show that both buspirone and 8-OH-DPAT significantly decrease pupil size in a dose-dependent manner. The 5-HT1A receptor antagonist WAY 100635 completely blocked both buspirone and 8-OH-DPAT-induced miosis, whereas 1-(2-pyrimidinyl) piperazine had no effect on pupil size. These results suggest that measurement of pupil size may be a useful biomarker for predicting the pharmacodynamics of new 5-HT1A receptor agonists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|