Potentiation of cytotoxicity against a CEA positive cell line by the bispecific antibody OH1 using LAK cells from cancer-bearing patients
| Autor: | Teru Hideshima, Y. Yamashita, Takayuki Shirakusa, Miki Baba |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Cancer Research Time Factors CD3 Complex Cell Survival CD3 medicine.medical_treatment Cell Mice SCID Mice Carcinoembryonic antigen Stomach Neoplasms Antibodies Bispecific medicine Animals Humans Killer Cells Lymphokine-Activated Cytotoxicity Aged Neoplasm Staging Lymphokine-activated killer cell biology Rectal Neoplasms business.industry Cell Membrane hemic and immune systems General Medicine Immunotherapy Middle Aged Survival Analysis Carcinoembryonic Antigen medicine.anatomical_structure Oncology Apoptosis Cell culture Colonic Neoplasms Immunology biology.protein Cancer research Female Gallbladder Neoplasms business |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Bispecific antibody, OH1 was developed, which simultaneously recognizes CD3 on T cells and carcinoembryonic antigen (CEA) on tumor cells. Although there was not significant difference, PBMCs pretreated with OH1 showed tendency to prolong survival of KATO III-injected SCID mice compared with control groups. although cytotoxicity of LAK cells from cancer-bearing patients was suppressed compared with that of cells of healthy donors, LAK cells from the patients pretreated with OH1 showed significantly increased cytotoxicity against KATO III cells. These results suggest that OH1 could be useful in immunotherapy with LAK cells for carcinomas that express CEA on the membrane. |
| Databáze: | OpenAIRE |
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