Symptomatic hyponatraemia caused by cylophosphamide
| Autor: | Christoph Eisenbach, Florian Lordick, Anne Katrin Berger, Frauke Bellos, Annika Siegmund |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pediatrics endocrine system diseases Cyclophosphamide medicine.medical_treatment Medicine Humans Intensive care medicine Antineoplastic Agents Alkylating Aged Chemotherapy Ifosfamide business.industry Acute hyponatraemia nutritional and metabolic diseases Hematology General Medicine nervous system diseases Oncology lipids (amino acids peptides and proteins) Female business medicine.drug Hyponatremia |
| Zdroj: | Onkologie. 32(5) |
| ISSN: | 1423-0240 |
| Popis: | Acute hyponatraemia after administration of alkylating agents such as cyclophosphamide or ifosfamide has been documented as an infrequent but life-threatening complication.A 69-year-old female patient with metastatic adenocarcinoma of the salivary glands presented with severe symptomatic hyponatraemia (nadir 112 mmol/l) after chemotherapy with cyclophosphamide, cisplatin, and doxorubicin. Serum sodium was carefully corrected at the intensive care unit. The patient recovered completely from her neurological symptoms within a couple of days. A literature review showed only few cases with cyclophosphamide-induced acute hyponatraemia, and to our knowledge this is the first case where hyponatraemia was seen with a dose of only 500 mg/m(2) of cyclophosphamide.Oncologists should be aware of cyclophosphamide-induced acute hyponatraemia as a rare but life-threatening side-effect, especially since its clinical features may mimic those of chemotherapy-induced nausea. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|