Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline
| Autor: | Jan Marcusson, Josefine Andin, Svante B. Ross, Carina Stenfors |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Amino Acid Transport System X-AG Amitriptyline Glutamic Acid Antidepressive Agents Tricyclic Glutamate Plasma Membrane Transport Proteins Rats Sprague-Dawley Cellular and Molecular Neuroscience Internal medicine medicine Glutamate aspartate transporter Animals RNA Messenger Molecular Biology Neurons Symporters biology Depression Metabotropic glutamate receptor 7 Metabotropic glutamate receptor 6 Brain Rats Excitatory Amino Acid Transporter 3 Endocrinology Glutamate dehydrogenase 1 Metabotropic glutamate receptor biology.protein NMDA receptor Metabotropic glutamate receptor 1 |
| Zdroj: | Molecular Brain Research. 126:74-77 |
| ISSN: | 0169-328X |
| Popis: | Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. The results lead to the suggestion that treatment with tricyclic antidepressants leads to changes in the EAAC1 mRNA expression in rat brain suggesting involvement of the glutamate system in the tricyclic treatment of depression. |
| Databáze: | OpenAIRE |
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