Celecoxib Tolerability in Patients with Hypersensitivity (Mainly Cutaneous Reactions) to Nonsteroidal Anti-Inflammatory Drugs
| Autor: | Francesco Gaeta, Marinella Viola, Donato Quaratino, Rocco Luigi Valluzzi, Sabrina Volpetti, Mario Caringi, Antonino Romano, Cristiano Caruso |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Hypersensitivity Immediate Male Adolescent Immunology Skin Diseases Vascular Placebo Drug Hypersensitivity Immunopathology medicine Humans Immunology and Allergy Cyclooxygenase Inhibitors skin and connective tissue diseases Aged Asthma Sulfonamides Cumulative dose business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Middle Aged medicine.disease Tolerability Celecoxib Pyrazoles Female Allergists business Anaphylaxis medicine.drug |
| Zdroj: | International Archives of Allergy and Immunology. 137:145-150 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000085794 |
| Popis: | Background: Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly observed in clinical practice, particularly among patients with chronic urticaria or asthma. The identification of a safe and reliable alternative is a frequent problem for both general practitioners and allergists. Methods: We assessed 120 patients (83 women and 37 men) who had experienced adverse reactions to one or more NSAIDs; 64 (53.3%) of them had reacted to only one NSAID (single reactors) and 56 (46.7%) to multiple NSAIDs (multiple reactors). Among our subjects, 76.7% reported cutaneous reactions, 8.3% respiratory symptoms, 10.8% both cutaneous and respiratory symptoms, and 4.2% anaphylaxis. All patients were subjected to a single-blind, placebo-controlled oral challenge with two different doses of celecoxib (50 + 150 mg 1 h later = cumulative dose of 200 mg). Results: None of the patients reacted to the placebo and only one (0.8%) suffered a reaction (urticaria) after the second dose of celecoxib. Conclusions: Celecoxib showed a 98.9% rate of tolerability in the 92 patients with exclusively cutaneous reactions and was well tolerated by all 28 subjects with NSAID-related respiratory or anaphylactic symptoms. |
| Databáze: | OpenAIRE |
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