Female Infertility and Serum Auto-antibodies: a Systematic Review

Autor: Alban Deroux, Laurence Bouillet, Camille Dunand-Faure, Pascale Hoffmann, Chantal Dumestre-Pérard
Přispěvatelé: Service de médecine interne [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service d'immunologie [CHU Grenoble], CHU de Grenoble, Barrière Naturelle et Infectiosité (TIMC-IMAG-BNI), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Anti-nuclear antibody
MESH: Trophoblasts
medicine.medical_treatment
Autoimmunity
Serum auto-antibodies
MESH: Antibodies
Antinuclear
Endometrium
0302 clinical medicine
MESH: Pregnancy
MESH: Antibodies
Antiphospholipid
Pregnancy
Adrenal Glands
Immunology and Allergy
MESH: Autoantibodies
Auto-immunity
MESH: Adrenal Glands
Unexplained infertility
education.field_of_study
030219 obstetrics & reproductive medicine
MESH: Infertility
Female
Obstetrics
Assisted reproduction
Female infertility
Reproductive technique
General Medicine
Anti-nuclear antibodies
Trophoblasts
3. Good health
MESH: Reproductive Techniques
Assisted
MESH: Endometrium
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Antibodies
Antinuclear
Antibodies
Antiphospholipid
Female
Immunomodulator
Thyroid function
Infertility
Female
Infertility
MESH: Ovary
medicine.medical_specialty
Reproductive Techniques
Assisted
Anti-phospholipid antibodies
Population
Fertilization in Vitro
03 medical and health sciences
MESH: Autoimmunity
medicine
Humans
education
Autoantibodies
Gynecology
In vitro fertilisation
MESH: Humans
business.industry
Ovary
medicine.disease
MESH: Fertilization in Vitro
030104 developmental biology
business
MESH: Female
Zdroj: Clinical Reviews in Allergy and Immunology
Clinical Reviews in Allergy and Immunology, Humana Press, 2017, 53 (1), pp.78-86. ⟨10.1007/s12016-016-8586-z⟩
ISSN: 1080-0549
DOI: 10.1007/s12016-016-8586-z⟩
Popis: International audience; On average, 10 % of infertile couples have unexplained infertility. Auto-immune disease (systemic lupus erythematosus, anti-phospholipid syndrome) accounts for a part of these cases. In the last 20 years, aspecific auto-immunity, defined as positivity of auto-antibodies in blood sample without clinical or biological criteria for defined diseases, has been evoked in a subpopulation of infertile women. A systematic review was performed (PUBMED) using the MESH search terms "infertility" and "auto-immunity" or "reproductive technique" or "assisted reproduction" or "in vitro fertilization" and "auto-immunity." We retained clinical and physiopathological studies that were applicable to the clinician in assuming joint management of both infertility associated with serum auto-antibodies in women. Thyroid auto-immunity which affects thyroid function could be a cause of infertility; even in euthyroidia, the presence of anti-thyroperoxydase antibodies and/or thyroglobulin are related to infertility. The presence of anti-phospholipid (APL) and/or anti-nuclear (ANA) antibodies seems to be more frequent in the population of infertile women; serum auto-antibodies are associated with early ovarian failure, itself responsible for fertility disorders. However, there exist few publications on this topic. The methods of dosage, as well as the clinical criteria of unexplained infertility deserve to be standardized to allow a precise response to the question of the role of serum auto-antibodies in these women. The direct pathogenesis of this auto-immunity is unknown, but therapeutic immunomodulators, prescribed on a case-by-case basis, could favor pregnancy even in cases of unexplained primary or secondary infertility.
Databáze: OpenAIRE
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