Survival Analysis of 272 Patients With Pancreatic Cancer Undergoing Combined Treatment
| Autor: | Renji Lin, Gang Zhao, Nida Cao, Ai-Guang Zhao, Jin-Kun Yang, Xiaolin Wang, Bing Han, Yadong Zhao |
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| Rok vydání: | 2015 |
| Předmět: |
Male
China medicine.medical_specialty medicine.medical_treatment Kaplan-Meier Estimate Gastroenterology Disease-Free Survival Internal medicine Pancreatic cancer medicine Humans Karnofsky Performance Status Medicine Chinese Traditional Radical surgery Survival analysis Aged Proportional Hazards Models Retrospective Studies Chemotherapy Proportional hazards model business.industry Hazard ratio Middle Aged Prognosis medicine.disease Combined Modality Therapy Survival Analysis Confidence interval Surgery Pancreatic Neoplasms Survival Rate Radiation therapy Treatment Outcome Complementary and alternative medicine Oncology Case-Control Studies Female business Follow-Up Studies |
| Zdroj: | Integrative Cancer Therapies. 14:133-139 |
| ISSN: | 1552-695X 1534-7354 |
| DOI: | 10.1177/1534735414564185 |
| Popis: | Background: In China, traditional Chinese herbal medicine (TCHM) has been widely used for pancreatic cancer. This retrospective, matched case-control study aimed to assess factors affecting the survival time of patients with pancreatic cancer. Methods: From 2004 to 2012, a total of 411 patients with pathologically confirmed pancreatic cancer were enrolled, and 272 patients were matched and divided into TCHM and non-TCHM groups (control group) based on received TCHM or not. The match was according to gender, age of onset, radiotherapy, and chemotherapy. Both groups received comprehensive treatments, the TCHM group simultaneously received the TCHM spleen-invigorating compound for more than 3 months. The Cox model was used for prognostic factor analysis and the Kaplan-Meier method for estimating median overall survival (OS) and disease-free survival (DFS). Results: In 130 patients with advanced pancreatic cancer, COX analysis showed the Karnofsky Performance Scale (KPS; P = .000), radiotherapy ( P = .003), and TCHM ( P = .001) were independent prognostic factors for OS, with median OS of 12.7 and 9.9 months in TCHM and non-TCHM groups, respectively (hazard ratio [HR] = 0.520; 95% confidence interval [CI] = 0.353-0.766; P = .033). In 142 patients undergoing radical surgery, KPS ( P = .000) and TCHM ( P = .000) were independent prognostic factors for OS and DFS, median OS was 23.8 and 12.4 months in TCHM and non-TCHM groups, respectively (HR = 0.373; 95% CI = 0.251-0.554; P = .000), and the median DFS was 21.5 and 10.2 months in TCHM and non-TCHM groups, respectively (HR = 0.352; 95% CI = 0.237-0.522; P = .000). Conclusions: KPS was an important prognostic factor of pancreatic cancer. Spleen-invigorating compounds could have an effect on improving the prognosis of pancreatic cancer patients |
| Databáze: | OpenAIRE |
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