Ofloxacin Otic Solution for Treatment of Otitis Externa in Children and Adults
| Autor: | Ronald N. Jones, Mindell Seidlin, Jack Milazzo |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Ofloxacin Staphylococcus aureus medicine.medical_specialty Hydrocortisone Drug Administration Schedule law.invention Cortisporin Anti-Infective Agents Randomized controlled trial Ambulatory care law Internal medicine Enterobacter cloacae Enterococcus faecalis medicine Humans Child Adverse effect Proteus mirabilis Polymyxin B Antibacterial agent business.industry Neomycin General Medicine Otitis Externa Surgery Solutions Clinical trial Drug Combinations Klebsiella pneumoniae Treatment Outcome Otitis Otorhinolaryngology Child Preschool Pseudomonas aeruginosa Female medicine.drug_brand medicine.symptom business medicine.drug |
| Zdroj: | Archives of Otolaryngology - Head and Neck Surgery. 123:1193-1200 |
| ISSN: | 0886-4470 |
| DOI: | 10.1001/archotol.1997.01900110047007 |
| Popis: | Objective: To compare the safety and efficacy of ofloxacin otic solution with those of Cortisporin otic solutions (neomycin sulfate, polymyxin B sulfate, and hydrocortisone) in otitis externa in adults and children. Design: Two randomized, evaluator-blind, multicenter trials, 1 each in children and adults. Setting: Twenty-three primary care and referral ambulatory care sites per trial. Patients: A total of 314 adults (12 years and older) and 287 children (younger than 12 years). Of the total, data for 247 adults and 227 children were considered clinically evaluable (CE), and those for 98 children and 98 adults were microbiologically evaluable (ME). Interventions: Ofloxacin (adults, 0.5 mL; children, 0.25 mL) twice daily or Cortisporin (adults, 0.2 mL; children, 0.15 mL) 4 times daily for 10 days. Main Outcome Measures: The CE subjects were cured if all signs and symptoms resolved at posttherapy (days 11-13) and test-of-cure (days 17-20) visits. The ME subjects had microbiological and clinical successes if they were cured and had microbiological eradication or presumed eradication. Results: Cure was observed in 82% and 97% of CE adults and children treated with ofloxacin and 84% and 95% of CE adults and children treated with Cortisporin, respectively. The most common pathogens at the pretherapy visit werePseudomonas aeruginosa, Staphylococcus aureus, and enteric bacilli. There were no statistically significant differences in clinical or microbiological and clinical cure or in the rates of adverse events between treatment groups. Conclusions: Ofloxacin given twice daily is as safe and effective as Cortisporin given 4 times daily for otitis externa. The bacteriological findings and treatment responses do not differ between adults and children. Arch Otolaryngol Head Neck Surg. 1997;123:1193-1200 |
| Databáze: | OpenAIRE |
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