Antioxidant properties ofFerulago angulataand its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats

Autor: Gökhan Oto, Fevzi Özgökçe, Hatice Kızıltaş, Suat Ekin, Serkan Yildirim, Esvet Akbas, Mahire Bayramoglu
Rok vydání: 2017
Předmět:
Male
Antioxidant
medicine.medical_treatment
cat
Pharmaceutical Science
Context (language use)
antioxidant capacity
010501 environmental sciences
Protective Agents
medicine.disease_cause
030226 pharmacology & pharmacy
01 natural sciences
Antioxidants
Dimethylnitrosamine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
N-Nitrosodimethylamine
Drug Discovery
ferulago angulata
medicine
Animals
Rats
Wistar
gsh-px
0105 earth and related environmental sciences
Pharmacology
Apiaceae
Traditional medicine
biology
Plant Extracts
Superoxide Dismutase
lcsh:RM1-950
Free Radical Scavengers
General Medicine
Catalase
biology.organism_classification
Rats
Oxidative Stress
Antioxidant capacity
lcsh:Therapeutics. Pharmacology
Liver
Complementary and alternative medicine
chemistry
Biochemistry
Ferulago angulata
Molecular Medicine
sod
Oxidative stress
Zdroj: Pharmaceutical Biology, Vol 55, Iss 1, Pp 888-897 (2017)
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2016.1270974
Popis: Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. ABSTRACT Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats. Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10mg/kg) for the first 7 days. FASB methanol extract (150 and 300mg/kg) was administered orally for 21 days. Results: a-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70±0.13, 0.29±0.03lg/g, 139.32±7.06lg/100g, 171.61±6.05mM ascorbic acid/g, 90.47±4.11mg GA/g and 37.39±2.85mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC50 67.34±4.14 and 64.87±4.68lg/mL, respectively. Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje