Reducing the frequency of respiratory tract infections in severe neurological disorders by inhaled antibiotics: a retrospective data analysis
| Autor: | Margarete Olivier, Florian Stehling, Maximilian Eckerland, Leopold Pichlmaier, Mathis Steindor, Claudia Bock |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Respiratory tract infections business.industry medicine.drug_class Antibiotics lcsh:R Medizin lcsh:Medicine Original Articles University hospital Inhaled antibiotics Retrospective data 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Interquartile range Internal medicine Respiratory Infections medicine 030212 general & internal medicine business Airway Neurological impairment |
| Zdroj: | ERJ Open Research, Vol 5, Iss 3 (2019) ERJ Open Research |
| ISSN: | 2312-0541 |
| Popis: | Background In patients with severe neurological impairment, recurrent respiratory tract infections frequently occur as a result of impaired clearance of airway secretions and microbial airway colonisation. We hypothesised that inhaled antibiotic therapy may improve the morbidity of these patients. Methods A retrospective data analysis of 20 patients (11 nontracheotomised and nine tracheotomised) with neurological impairment and microbial airway colonisation was carried out at a children's university hospital. Two questionnaires that asked about the number of respiratory tract infections, antibiotic therapies and hospitalisations were distributed to the patients/caregivers: a first questionnaire representing the 12 months prior to the initiation of inhaled antibiotics and a second questionnaire describing the first 12 months under therapy. Results During the first 12 months of therapy, the frequency of respiratory tract infections among all participants was reduced from a mean of 6.8 episodes (median (interquartile range (IQR)) 6.0 (4.0–10.0) episodes) to a mean of 2.5 episodes (median (IQR) 2.0 (1.0–3.0) episodes; p Inhaled antibiotic therapy offers a novel approach to the prevention of respiratory tract infections in patients with severe neurological impairment who have chronic microbial airway colonisation and recurrent respiratory tract infections http://bit.ly/2HQRyz0 |
| Databáze: | OpenAIRE |
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