Mechanisms of hemagglutinin targeted influenza virus neutralization
| Autor: | Hans J. W. M. Korse, Jaap Goudsmit, Robert H. E. Friesen, Ted Kwaks, Ronald Vogels, Boerries Brandenburg, Wouter Koudstaal, Miriam V. Bujny, Chan Tang, Jarek Juraszek, Jason J. Otterstrom, Vincent Klaren, Antoine M. van Oijen |
|---|---|
| Přispěvatelé: | Molecular Biophysics, Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
Immunoblotting Hemagglutinin (influenza) VACCINE lcsh:Medicine EPITOPE medicine.disease_cause Monoclonal antibody A VIRUSES Virus Epitope Madin Darby Canine Kidney Cells Epitopes Dogs Influenza A Virus H1N1 Subtype Immune system FUSION Microscopy Electron Transmission Viral life cycle Influenza A virus medicine Animals Humans lcsh:Science SPECTRUM Multidisciplinary biology lcsh:R Antibodies Monoclonal RECOGNIZES Antibodies Neutralizing Virology INSIGHTS Hemagglutinins PROSPECTS B-CELLS Microscopy Electron Scanning biology.protein Electrophoresis Polyacrylamide Gel lcsh:Q Antibody MONOCLONAL-ANTIBODIES Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 12, p e80034 (2013) PLoS ONE, 8(12):e80034. PUBLIC LIBRARY SCIENCE PLoS ONE PLoS ONE, 8(12). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals. |
| Databáze: | OpenAIRE |
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