Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay
| Autor: | Philip R. Fox, Mark A. Oyama, Bonnie K. Lefbom, Teresa C. DeFrancesco, Thaibinh P. Nguyenba, Barret J. Bulmer, Rebecca L. Stepien, John E. Rush, K Lamb, Linda B. Lehmkuhl, Heidi B. Kellihan, Sonya G. Gordon, Melanie J Hezzell, Suzanne M. Cunningham, John M. MacGregor, Darcy B. Adin |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.drug_class Physical examination Enzyme-Linked Immunosorbent Assay Standard Article Asymptomatic Canine Dogs Internal medicine Heart rate Natriuretic Peptide Brain Natriuretic peptide medicine Animals cardiovascular diseases Dog Diseases Heart Failure General Veterinary Respiratory distress medicine.diagnostic_test business.industry Respiratory disease medicine.disease Standard Articles Peptide Fragments Cross-Sectional Studies Dyspnea Heart failure Cardiology cardiovascular system Female medicine.symptom business Biomarkers |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Background Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD). Hypothesis/Objectives Determine the utility of plasma N-terminal pro-brain natriuretic peptide concentration [NT-proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity. Animals Client-owned dogs (n = 291). Methods Multicenter, cross-sectional, prospective investigation. Medical history, physical examination, echocardiography, and thoracic radiography classified 113 asymptomatic dogs (group 1, n = 39 without HD; group 2, n = 74 with HD), and 178 with respiratory distress (group 3, n = 104 respiratory disease, either with or without concurrent HD; group 4, n = 74 with congestive heart failure [CHF]). HD severity was graded using International Small Animal Cardiac Health Council (ISACHC) and ACVIM Consensus (ACVIM-HD) schemes without knowledge of [NT-proBNP] results. Receiver-operating characteristic curve analysis assessed the capacity of [NT-proBNP] to discriminate between dogs with cardiac and noncardiac respiratory distress. Multivariate general linear models containing key clinical variables tested associations between [NT-proBNP] and HD severity. Results Plasma [NT-proBNP] (median; IQR) was higher in CHF dogs (5,110; 2,769–8,466 pmol/L) compared to those with noncardiac respiratory distress (1,287; 672–2,704 pmol/L; P 2,447 pmol/L discriminated CHF from noncardiac respiratory distress (81.1% sensitivity; 73.1% specificity; area under curve, 0.84). A multivariate model comprising left atrial to aortic ratio, heart rate, left ventricular diameter, end-systole, and ACVIM-HD scheme most accurately associated average plasma [NT-proBNP] with HD severity. Conclusions and Clinical Importance Plasma [NT-proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT-BNP] increased significantly as a function of HD severity using the ACVIM-HD classification scheme. |
| Databáze: | OpenAIRE |
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