Synthesis, characterization, and anti-plasmodial activity of 2,6-substituted benzothiazole derivatives
| Autor: | Sowmiya Rajamani, Pachiappan Perumal, Kannan Kulanthai, Gnanavel Sadhasivam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Chemistry Stereochemistry lcsh:RM1-950 Plasmodium falciparum Anti-plasmodial Benzothiazole Synthesis biology.organism_classification 01 natural sciences Giemsa stain 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound lcsh:Therapeutics. Pharmacology parasitic diseases |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 11, Iss 2 (2016) Bangladesh Journal of Pharmacology, Vol 11, Iss 2, Pp 321-327 (2016) |
| ISSN: | 1991-0088 |
| Popis: | Six compounds of benzothiazole derivatives were synthesized, and structures were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The resulting compounds were evaluated for anti-plasmodial activity against Plasmodium falciparum by Giemsa stain. Among them the compounds 3b and 4 showed potent anti-plasmodial activity against P. falciparum. The com-pounds 3a, 5a, 5b also showed moderate anti-plasmodial activity. The structure-activity relationships of benzothiazole derivatives also discussed which were useful for exploring and developing benzothiazole derivatives as novel anti-malarial drugs. |
| Databáze: | OpenAIRE |
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