Origin and impact of plasmid-mediated extended-spectrum beta-lactamases
| Autor: | Guillaume Arlet, Alain Philippon, P. H. Lagrange |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Gram-negative bacteria medicine.drug_class Klebsiella pneumoniae Cephalosporin medicine.disease_cause beta-Lactam Resistance beta-Lactamases Microbiology Clavulanic Acids Plasmid Clavulanic acid Gram-Negative Bacteria polycyclic compounds medicine chemistry.chemical_classification biology Pseudomonas aeruginosa General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Infectious Diseases Enzyme chemistry Mutation Bacteroides fragilis Plasmids medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 13:S17-S29 |
| ISSN: | 1435-4373 0934-9723 |
| Popis: | Resistance to oxyimino cephalosporins was originally highlighted by the emergence of plasmid-encoded extended-spectrum beta-lactamases deriving by mutation from TEM-1, TEM-2 and SHV type enzymes (class A). The broader spectrum of resistance produced by these enzymes is related to more amino acid substitutions, but susceptibility to seven alpha-methoxyimino cephalosporins and carbapenems was preserved until recently. Clavulanate-sensitive extended-spectrum beta-lactamases are distributed worldwide, mainly among Klebsiella pneumoniae isolates. Novel clavulanate-sensitive extended-spectrum beta-lactamases deriving from other class A enzymes (e.g. MEN-1 from beta la OXY, OXA-11 in Pseudomonas aeruginosa from PSE-2) have been reported. Recently, clavulanate-resistant extended-spectrum beta-lactamases (class C) were encountered amongst single isolates, mostly Klebsiella pneumoniae. These cephalosporinases or cefamycinases (usually chromosomally mediated) have expanded the spectrum of plasmid-encoded resistance to include seven alpha-methoxyimino cephalosporins. Thus far, only two isolates (1 Pseudomonas aeruginosa, 1 Bacteroides fragilis), both recovered in Japan, with plasmid-mediated resistance to carbapenems have been found. |
| Databáze: | OpenAIRE |
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