Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum
| Autor: | C.P. Davis, Robert C. Fader, E A Weaver, R M Goldblum, Armond S. Goldman, C. W. Houston |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Immunoglobulin A Immunodiffusion Adolescent Klebsiella pneumoniae Immunology Enzyme-Linked Immunosorbent Assay Cell Fractionation Microbiology Pilus Humans Binding selectivity biology Colostrum biology.organism_classification Antibodies Bacterial Infectious Diseases Fimbriae Bacterial Immunoglobulin A Secretory biology.protein Female Parasitology Cell fractionation Antibody Research Article |
| Zdroj: | Infection and Immunity. 38:496-501 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.38.2.496-501.1982 |
| Popis: | Immunoglobulin A antibodies with binding specificity for purified Klebsiella pneumoniae type 1 pili were detected by an enzyme-linked immunosorbent assay in 20 of 21 human samples (95%). The concentrations of secretory immunoglobulin A antibody in colostrum directed against the pili were calculated by comparison of experimental enzyme-linked immunosorbent assay values with values obtained from known secretory immunoglobulin A concentrations. The presence of antibodies to K. pneumoniae type 1 pili was confirmed by double diffusion-gel studies with selected specimens of colostrum. This study shows that in the majority of human colostral samples examined, secretory immunoglobulin A antibodies with specificity for K. pneumoniae type 1 pili can be commonly found in variable, but frequently high, concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|