Pentoxifylline Potentiates Antiepileptic Activity of Diazepam on the Model of Treatment-Resistant Focal Epilepsy
| Autor: | V. A. Polyasnyi, G. A. Drozdova, V. F. Mustyatsa, E. V. Kobolev, L. S. Godlevsky |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_treatment Penicillins Pharmacology General Biochemistry Genetics and Molecular Biology Pentoxifylline Epilepsy Combined treatment Kindling Neurologic medicine Animals Rats Wistar Treatment resistant Cerebral Cortex Diazepam Kindling business.industry Brain Drug Synergism Free Radical Scavengers General Medicine medicine.disease Brain Waves Rats medicine.anatomical_structure Anticonvulsant Cerebral cortex Pentylenetetrazole Anticonvulsants Epilepsies Partial business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 154:326-328 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated. |
| Databáze: | OpenAIRE |
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