Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
| Autor: | Arno Villringer, Nathalie Beinhölzl, Rachel G. Zsido, Fabian A. Piecha, Harald E. Möller, Bernhard Sehm, Ulrike Scharrer, Julia Sacher, Gergana Zheleva, Eoin Molloy, Ralf Regenthal, Karsten Mueller, Vadim V. Nikulin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Science Citalopram Article Learning and memory Young Adult 03 medical and health sciences 0302 clinical medicine Neurochemical Thalamus Motor control Cerebellum Neuroplasticity mental disorders medicine Humans Learning Escitalopram 030304 developmental biology Motor Neurons Pharmacology 0303 health sciences Neuronal Plasticity Multidisciplinary medicine.diagnostic_test business.industry Putamen Neurochemistry Magnetic Resonance Imaging Medicine Female Sequence learning Nerve Net Motor learning business Functional magnetic resonance imaging Neuroscience Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram. |
| Databáze: | OpenAIRE |
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