The combined utility of myeloperoxidase (MPO) and paraoxonase 1 (PON1) as two important HDL-associated enzymes in coronary artery disease: Which has a stronger predictive role?
| Autor: | Mehryar Zargari, Atena Variji, Babak Bagheri, Saeid Abediankenari, Ahad Alizadeh, Yasaman Shokri, Samane Fallahpour, Abdolkarim Mahrooz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty animal diseases Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment Coronary artery disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Odds Ratio medicine Humans False Positive Reactions In patient Aged Peroxidase chemistry.chemical_classification biology Receiver operating characteristic Aryldialkylphosphatase business.industry Paraoxonase Middle Aged medicine.disease PON1 030104 developmental biology Enzyme ROC Curve chemistry Myeloperoxidase biology.protein Cardiology Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 280:7-13 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2018.11.004 |
| Popis: | Serum paraoxonase 1 (PON1) and myeloperoxidase (MPO) are HDL-associated enzymes that contribute significantly to the formation of dysfunctional HDL. The present study thus seeks to comparatively analyze the predictive role of PON1, MPO and the MPO/PON1 ratio and to also evaluate which one has a stronger predictive role in their combined utility as an MPO/PON1 ratio in coronary artery disease (CAD).PON1 activity and MPO concentrations were determined in patients with established CAD and those without significant CAD. Receiver operating characteristic (ROC) curves were drawn by plotting true positivity versus false positivity.The ROC curve analyses showed that PON1 (AUC = 61%, p = 0.003) and MPO/PON1 (AUC = 60%, p = 0.01) have a better diagnostic performance than MPO (AUC = 50%, p = 0.42) in detecting patients with CAD. PON1 and MPO/PON1 were found to have a significantly stronger discriminatory power for the age range ≥52 and 60 years (AUC = 69%, p = 0.008 for PON1; AUC = 66%, p = 0.022 for MPO/PON1). The multivariate analysis revealed PON1 as an independent variable that was significantly associated with the multi-vessel disease [odds ratio (OR) = 0.98; p = 0.017]. At the cutoff point of 30 μmol/mL/min for PON1 and 1.85 for MPO/PON1, specificities were 97% and 73% and sensitivities 30% and 54% for discriminating patients with single-vessel disease from non-CAD subjects.The diagnostic performance of PON1 alone was comparable to that of the MPO/PON1 ratio for CAD risk assessment; however, MPO may increase the true positive rate. A larger number of blocked vessels seems to be associated with an increased predictive power for both PON1 and MPO/PON1. Recent data support the fact that PON1 and MPO may potentially be appropriate therapeutic targets for preventing CAD. |
| Databáze: | OpenAIRE |
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