Pretreatment with d-tubocurarine, vecuronium, and pancuronium attenuates succinylcholine-induced increases in plasma norepinephrine concentrations in humans
| Autor: | Shuzo Oshita, Hiroshi Takeshita, Sadahei Denda, Futami Kosaka, Yoshiki Fujiwara |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Tubocurarine Stimulation Blood Pressure Succinylcholine Fasciculation Norepinephrine Plasma norepinephrine Heart Rate Internal medicine Heart rate Medicine Humans Pancuronium Saline Vecuronium Bromide business.industry Sympathetic ganglion Stimulation Chemical Anesthesiology and Pain Medicine medicine.anatomical_structure Blood pressure Endocrinology Anesthesia Depression Chemical Catecholamine Female medicine.symptom business medicine.drug |
| Zdroj: | Anesthesia and analgesia. 72(1) |
| ISSN: | 0003-2999 |
| Popis: | We studied in patients the effect of d-tubocurarine, which has sympathetic ganglion blocking action, on succinylcholine-induced increases in plasma levels of catecholamines, and compared it with the effects of vecuronium and pancuronium, which have little sympathetic ganglion blocking action. Thirty-two patients were divided into five groups: seven were given 3 mL saline; seven received 1 mg/kg succinylcholine; and six, seven, and five patients were given 0.08 mg/kg d-tubocurarine, 0.01 mg/kg vecuronium, and 0.01 mg/kg pancuronium, respectively, all of which were injected 5 min before 1 mg/kg succinylcholine. Succinylcholine alone significantly increased plasma norepinephrine concentrations, systolic blood pressure, and heart rate from 187 +/- 39 pg/mL (mean +/- SEM), 93 +/- 2 mm Hg, and 77 +/- 4 beats/min to 429 +/- 61 pg/mL, 120 +/- 7 mm Hg, and 102 +/- 6 beats/min, respectively, with onset of fasciculations. Pretreatment with d-tubocurarine, vecuronium, and pancuronium significantly and equally attenuated both the fasciculations and the cardiovascular responses to succinylcholine. These results suggest that the sympathetic ganglion blocking action of neuromuscular relaxants when given before succinylcholine is not an important factor in attenuation of succinylcholine-induced increases in plasma levels of catecholamines. |
| Databáze: | OpenAIRE |
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