Germ Cell Tumor: Differentiation of Viable Tumor, Mature Teratoma, and Necrotic Tissue with FDG PET and Kinetic Modeling
| Autor: | Michael F. Clarke, K. R. Zasadny, H B Grossman, I R Francis, Richard L. Wahl, Yoshifumi Sugawara |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Fluorine Radioisotopes Pathology medicine.medical_specialty Neoplasm Residual Necrosis medicine.medical_treatment Standardized uptake value Models Biological Diagnosis Differential Fluorodeoxyglucose F18 medicine Humans Neoplasm Radiology Nuclear Medicine and imaging Retroperitoneal Neoplasms Chemotherapy Germ cell neoplasm medicine.diagnostic_test business.industry Teratoma Mediastinum medicine.disease medicine.anatomical_structure Positron emission tomography Germinoma Radiopharmaceuticals medicine.symptom Nuclear medicine business Tomography Emission-Computed |
| Zdroj: | Radiology. 211:249-256 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | To evaluate the feasibility of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in patients with germ cell tumor (GCT) to monitor treatment and differentiate residual masses after chemotherapy.Twenty-six FDG PET studies were performed in 21 patients with GCT, FDG uptake of tumors was interpreted visually, and the lean standardized uptake value (SUVlean) was determined. Tumor kinetic rate constants (K1, k2, k3) and net rate of FDG phosphorylation (K = [K1.k3]/[k2 + k3]) in tumors were calculated from the dynamic data by means of a three-compartment model, assuming k4 = 0.Viable tumors (n = 10) showed intense FDG uptake and could easily be differentiated visually from mature teratoma (n = 6) and necrosis or scar (n = 10). The SUVlean of residual viable tumors (4.51 +/- 1.34 [mean +/- SD]) was higher than that of mature teratoma (1.38 +/- 0.71) and necrosis or scar (1.05 +/- 0.29) (P.05). Although neither the visual interpretation nor SUVlean differentiated mature teratoma from necrosis or scar, there were statistically significant differences in the kinetic rate constants K1 and K between mature teratoma and necrosis or scar as follows: K1, 0.113 mL/min/g +/- 0.026 versus 0.036 mL/min/g +/- 0.005 (P.05); K, 0.005 mL/min/g +/- 0.003 versus 0.0008 mL/min/g +/- 0.0001 (P.05).FDG PET with kinetic analysis appears to be a promising method for management of disease in patients with GCT after treatment. |
| Databáze: | OpenAIRE |
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