An investigation of the in vivo formation of octachlorodibenzo- p -dioxin
| Autor: | T.O. Tiernan, Vernon J. Feil, Janice K. Huwe, Richard G. Zaylskie |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pentachlorophenol
Polychlorinated Dibenzodioxins Environmental Engineering food.ingredient Health Toxicology and Mutagenesis Polychlorinated dibenzodioxins Dioxins Rats sprague dawley Rats Sprague-Dawley chemistry.chemical_compound food In vivo Animals Plant Oils Environmental Chemistry Sample preparation Chromatography Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution Diet Rats Octachlorodibenzo-p-dioxin chemistry Environmental chemistry Peanut oil Peanut Oil |
| Zdroj: | Chemosphere. 40:957-962 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/s0045-6535(99)00339-2 |
| Popis: | The in vivo formation of dioxins from chemical precursors was investigated in rats. Sprague-Dawley rats were fed pentachlorophenol or a predioxin in peanut oil for 14 days. Mass balance calculations indicated that pentachlorophenol was not converted to dioxins; however, the predioxin, nonachloro-2-phenoxyphenol, was converted to OCDD. Conversion of the predioxin ranged from 0.5% to 153% and depended on the amount of predioxin and OCDD present in the diet. The analytical procedures used for sample preparation did not appear to cause conversion of the predioxin to OCDD. The mechanism for biological conversion may be enzymatic or spontaneous. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect