Polymorphisms of CHRNA3 and CHRNA5 : Head and neck cancer and cigarette consumption intensity in a Brazilian population
| Autor: | Isabela Firigato, Mariana Rosa da Silva, Otávio Alberto Curioni, Juliana De Antonio, Fernanda de Toledo Gonçalves, Gilka Jorge Fígaro Gattás |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology Heterozygote medicine.medical_specialty lcsh:QH426-470 Homozygous genotype Nerve Tissue Proteins Receptors Nicotinic 030105 genetics & heredity Polymorphism Single Nucleotide Nicotine 03 medical and health sciences cigarette consumption Surveys and Questionnaires Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Genotyping Genetic Association Studies Genetics (clinical) biology business.industry CHRNA5 Smoking Head and neck cancer Original Articles medicine.disease lcsh:Genetics 030104 developmental biology Head and Neck Neoplasms Case-Control Studies CHRNA3 biology.protein Female Original Article head and neck cancer Brazilian population business Brazil medicine.drug |
| Zdroj: | Molecular Genetics & Genomic Medicine Molecular Genetics & Genomic Medicine, Vol 7, Iss 12, Pp n/a-n/a (2019) |
| ISSN: | 2324-9269 |
| Popis: | Background Cigarette consumption has been identified as the main non‐etiological factor in head and neck cancer (HNC) development. One of the main compounds in cigarettes is nicotine, which binds directly to nicotine acetylcholine receptors (nAchRs) in the body, which are encoded by different genes of the CHRNA family. Polymorphisms in some of these genes have been studied in relation to the risk of HNC and cigarette consumption intensity. The aim of this study was to evaluate whether there were associations between the CHRNA3 (rs578776) and CHRNA5 (rs16969968) polymorphisms and HNC risk and between the polymorphisms and the intensity of cigarette consumption. Methods A total of 1,067 individuals from Heliopolis Hospital in São Paulo were investigated, including 619 patients with HNC and 448 patients without diagnosed tumors. All participants answered a questionnaire about sociodemographic information and cigarette consumption data. The polymorphisms were determined by TaqMan genotyping by real‐time PCR. Results The polymorphisms studied, rs578776 (CHRNA3) and rs16969968 (CHRNA5), did not have an association with HNC risk, but the rs16969968 homozygous genotype was associated with increased cigarette consumption intensity (OR 1.93, 95% CI 1.05–3.58). Conclusion The polymorphism CHRNA5 can be considered an indirect risk factor for neoplasms in these Brazilian samples when cigarette consumption increased. The gene CHRNA5, that encoded the α5 subunit of nicotinic receptor, increased the cigarette consumption intensity in Brazilian sample. Once tobacco consumed is a risk factor to the head and neck cancer development, these polymorphism can be considered an indirect risk factor for these neoplasm. |
| Databáze: | OpenAIRE |
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