Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region

Autor: Taís Nóbrega de Sousa, Camilla V. Pires, Jéssica R. S. Alves, Bruno Antonio Marinho Sanchez, Helena L. Costa, John H. Adams, Leticia M. Torres, Luzia H. Carvalho, Cor Jesus Fernandes Fontes, Francis B. Ntumngia, Flora S. Kano, Irene S. Soares, Barbara A. S. Lima, Ruth B. Paula
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Plasmodium
Time Factors
Physiology
Plasmodium vivax
Antibodies
Protozoan
Antibody Response
Pathology and Laboratory Medicine
Biochemistry
law.invention
Serology
Cohort Studies
0302 clinical medicine
law
Immune Physiology
Global health
Medicine and Health Sciences
Enzyme-Linked Immunoassays
Immune Response
Protozoans
Multidisciplinary
Immune System Proteins
biology
Malarial Parasites
Eukaryota
Middle Aged
3. Good health
Transmission (mechanics)
Population study
Medicine
Female
Antibody
Brazil
Research Article
Adult
Rainforest
Science
030231 tropical medicine
Immunology
Research and Analysis Methods
Antibodies
03 medical and health sciences
Parasite Groups
parasitic diseases
medicine
Malaria
Vivax
Parasitic Diseases
Humans
PLASMODIUM
Antigens
Immunoassays
Organisms
Biology and Life Sciences
Proteins
Apical membrane
medicine.disease
biology.organism_classification
Tropical Diseases
Parasitic Protozoans
Malaria
030104 developmental biology
Cross-Sectional Studies
biology.protein
Immunologic Techniques
Parasitology
Apicomplexa
Biomarkers
Follow-Up Studies
Zdroj: PLoS ONE, Vol 13, Iss 11, p e0207244 (2018)
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1932-6203
Popis: Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even in low malaria transmission settings, such as the Amazon basin, where progress in malaria control has caused a remarkable reduction in case incidence, a recent increase in P. vivax transmission demonstrates the continued vulnerability of P.vivax-exposed populations. As part of a search for complementary approaches to P.vivax surveillance in areas in which adults are the majority of the exposed-population, here we evaluated the potential of serological markers covering a wide range of immunogenicity to estimate malaria transmission trends. For this, antibodies against leading P. vivax blood-stage vaccine candidates were assessed during a 9 year follow-up study among adults exposed to unstable malaria transmission in the Amazon rainforest. Circulating antibody levels against immunogenic P. vivax proteins, such as the Apical Membrane Antigen-1, were a sensitive measure of recent P. vivax exposure, while antibodies against less immunogenic proteins were indicative of naturally-acquired immunity, including the novel engineered Duffy binding protein II immunogen (DEKnull-2). Our results suggest that the robustness of serology to estimate trends in P.vivax malaria transmission will depend on the immunological background of the study population, and that for adult populations exposed to unstable P.vivax malaria transmission, the local heterogeneity of antibody responses should be considered when considering use of serological surveillance.
Databáze: OpenAIRE
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