Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation
| Autor: | Naval Daver, Hagop M. Kantarjian, Jorge E. Cortes, G. Garcia-Manero, E. Jabbour, Wei Qiao, Sherry Pierce, Tapan M. Kadia, Yiming Chen, M. de Lima, L. V. Abruzzo, Susan O'Brien, Farhad Ravandi, Partow Kebriaei, Stephan Faderl, Zeev Estrov |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Myeloid Adolescent Chromosomal translocation Biology Translocation Genetic Article Young Adult Risk Factors Internal medicine medicine Humans Transplantation Homologous Aged Aged 80 and over Chromosomes Human Pair 11 Myeloid leukemia Adult Acute Myeloid Leukemia Karyotype Hematology Middle Aged medicine.disease Prognosis Transplantation Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Karyotyping Immunology Female Bone marrow Stem Cell Transplantation |
| Zdroj: | Leukemia. 27(4) |
| ISSN: | 1476-5551 |
| Popis: | The clinical features and outcomes of 148 patients with acute myeloid leukemia (AML) and 11q23 chromosomal abnormalities were compared with those of 2640 patients with non-11q23 AML. Patients with t(9;11)), t(6;11), or other 11q23 balanced translocations [t(11;v)(q23;v)] presented at a younger age and with higher percentage of bone marrow blasts. Unbalanced 11q23 abnormalities were commonly associated with deletions of chromosomes 5q, 7q and/or complex karyotypes. In multivariate analysis, when compared to patients with non-11q23 AML and unfavorable risk karyotype, there was a significant difference in overall survival (OS) for patients with t(9;11) (P = .004), whereas there were no difference in OS for patients with t(6;11) (P = .62), t(11;19) (P = 0.20), and unbalanced 11q23 aberrations (P = .85) or t(11;v)(q23;v) (P = 0.59), indicating that t(9;11) has an independent intermediate prognostic factor, with all others poor prognostic factors for OS; this was further confirmed by comparing them with patients with non-11q23 AML and intermediate risk karyotype. Using intention-to treat analysis based on donor availability, we also noted that allogeneic stem cell transplant (SCT) in first remission had a significant benefit towards improving OS (P < 0.001) and relapse-free survival (P |
| Databáze: | OpenAIRE |
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