Birth outcomes of pregnancies fathered by men with multiple sclerosis
| Autor: | Helen Tremlett, M. van der Kop, Feng Zhu, Ellen Lu, Anthony Traboulsee, Anne Synnes, Leanne Dahlgren, Yinshan Zhao, A D Sadovnick |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Multiple Sclerosis Time Factors Databases Factual Birth weight Disease duration Population General Population Cohort Gestational Age Risk Assessment Disability Evaluation Fathers Pregnancy Risk Factors medicine Birth Weight Humans Registries education education.field_of_study Expanded Disability Status Scale British Columbia Obstetrics business.industry Multiple sclerosis Infant Newborn Pregnancy Outcome Gestational age medicine.disease Neurology Multivariate Analysis Linear Models Female Neurology (clinical) business |
| Zdroj: | Journal of the Neurological Sciences. 333:e381 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2013.07.1385 |
| Popis: | We linked several population-based clinical and health administrative databases in British Columbia, Canada. We identified and compared birth outcomes of pregnancies fathered by men with multiple sclerosis (MS) ( n=202) and men from a frequency-matched general population cohort ( n=981) between 1996 and 2010. Using multivariate models, we analyzed the association of paternal MS, disease duration at conception and disability (as measured by the Expanded Disability Status Scale) with birth weight and gestational age. Paternal MS and MS-related clinical factors were not significantly associated with birth outcomes ( p>0.05). This study provides assurance to expecting fathers with MS and their families. |
| Databáze: | OpenAIRE |
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