Basic Fibroblast Growth Factor as a Candidate Tumor Marker for Renal Cell Carcinoma
| Autor: | Masaaki Terada, Tadao Kakizoe, Eigoro Okajima, Takashi Futami, Seiichiro Ozono, Hisako Yamaguchi, Yuzo Ichimori, Kunihiko Arai, Yoshihiko Hirao, Kiyohide Fujimoto |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Basic fibroblast growth factor Fibroblast growth factor Nephrectomy Article Enzyme immunoassay Renal Veins Immunoenzyme Techniques chemistry.chemical_compound Renal cell carcinoma Internal medicine Biomarkers Tumor medicine Carcinoma Humans Tumor marker Carcinoma Renal Cell Kidney Epithelioma business.industry medicine.disease Kidney Neoplasms Endocrinology medicine.anatomical_structure Oncology chemistry Fibroblast Growth Factor 2 business Urogenital Neoplasms |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1995.tb03037.x |
| Popis: | The present investigation was conducted to determine serum levels of basic fibroblast growth factor (FGF) by enzyme immunoassay in patients with various urogenital tumors. Renal cell carcinoma had a higher tendency (28 of 52, 53.8%) toward increased serum levels of basic FGF than any of the other urogenital tumors, and increased serum basic FGF was detected more frequently in patients with advanced renal cell carcinoma. Analysis of histological pattern indicated that renal cell carcinoma with a solid or tubular component is more likely to produce basic FGF. However, no significant difference was seen between the percentage of clear cell type tumor patients with increased serum basic FGF (50.0%) and the percentage of granular cell type tumor patients with increased serum basic FGF (66.7%). Five of 8 patients with renal cell carcinoma who underwent selective renal venous sampling before nephrectomy showed increased serum basic FGF in the renal vein from the affected kidney. After resection of the affected kidney to remove the cancer, serum basic FGF disappeared within 2 weeks. However, residual huge tumor or postoperative disease prolonged the increased levels of basic FGF in 2 patients, indicating that basic FGF is produced from and secreted by tumor tissue itself. These findings suggest that serum basic FGF can be useful in the diagnosis, and in evaluating the prognosis, of patients with renal cell carcinoma. |
| Databáze: | OpenAIRE |
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