Fatal Nocardia farcinica Bacteremia Diagnosed by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry in a Patient with Myelodysplastic Syndrome Treated with Corticosteroids

Autor: F. Guercini, Francesco Bistoni, Giancarlo Agnelli, Amedeo Moretti, Antonella Mencacci, Angela Cardaccia, Leone Furbetta, Christian Leli
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Case Reports in Medicine
Case Reports in Medicine, Vol 2013 (2013)
ISSN: 1687-9635
1687-9627
Popis: Nocardia farcinicais a Gram-positive weakly acid-fast filamentous saprophytic bacterium, an uncommon cause of human infections, acquired usually through the respiratory tract, often life-threatening, and associated with different clinical presentations. Predisposing conditions forN. farcinicainfections include hematologic malignancies, treatment with corticosteroids, and any other condition of immunosuppression. Clinical and microbiological diagnoses ofN. farcinicainfections are troublesome, and the isolation and identification of the etiologic agent are difficult and time-consuming processes. We describe a case of fatal disseminated infection in a patient with myelodysplastic syndrome, treated with corticosteroids, in whichN. farcinicahas been isolated from blood culture and identified by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry. The patient died after 18 days of hospitalization in spite of triple antimicrobial therapy.Nocardia farcinicainfection should be suspected in patients with history of malignancy, under corticosteroid therapy, suffering from subacute pulmonary infection,and who do not respondto conventional antimicrobial therapy. Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry can be a valuable tool for rapid diagnosis of nocardiosis.
Databáze: OpenAIRE
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