Immunohistochemical characterization of feline mast cell tumors
| Autor: | C. L. Mallett, Corey F. Saba, E. W. Howerth, Carlos O. Rodriguez, Kenneth M. Rassnick, Michael O. Childress, Nicole C. Northrup, Tracy L. Gieger |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Serotonin Skin Neoplasms Mast-Cell Sarcoma Spleen Biology Cat Diseases Mast cell tumors chemistry.chemical_compound medicine Animals Mast Cells Anatomic Location Skin CATS General Veterinary CD117 Prognosis Immunohistochemistry Gastrointestinal Tract Proto-Oncogene Proteins c-kit medicine.anatomical_structure chemistry biology.protein Cats Histamine Mastocytosis |
| Zdroj: | Veterinary pathology. 50(1) |
| ISSN: | 1544-2217 |
| Popis: | Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin ( n = 29), spleen ( n = 17), and gastrointestinal (GI) tract ( n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences. |
| Databáze: | OpenAIRE |
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