Thalamic-Medial Temporal Lobe Connectivity Underpins Familiarity Memory
| Autor: | Andrew R. Mayes, Alex Kafkas, Daniela Montaldi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Mediodorsal Thalamic Nucleus Cognitive Neuroscience Thalamus pulvinar Stimulus (physiology) recognition memory 050105 experimental psychology Temporal lobe 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine Mediodorsal thalamus Neural Pathways anterior thalamus Humans 0501 psychology and cognitive sciences mediodorsal thalamus Ventrolateral Thalamus Recognition memory Perirhinal Cortex Ventral Thalamic Nuclei Recall Functional connectivity Functional Neuroimaging 05 social sciences Recognition Psychology Magnetic Resonance Imaging Temporal Lobe medial temporal lobe Anterior Thalamic Nuclei Mental Recall Parahippocampal Gyrus Female Original Article Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex (New York, NY) Kafkas, A, Mayes, A & Montaldi, D 2020, ' Thalamic-medial temporal lobe connectivity underpins familiarity memory ', Cerebral cortex (New York, N.Y. : 1991) . https://doi.org/10.1093/cercor/bhz345 |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhz345 |
| Popis: | The neural basis of memory is highly distributed, but the thalamus is known to play a particularly critical role. However, exactly how the different thalamic nuclei contribute to different kinds of memory is unclear. Moreover, whether thalamic connectivity with the medial temporal lobe (MTL), arguably the most fundamental memory structure, is critical for memory, remains unknown. We explore these questions using an fMRI recognition memory paradigm that taps familiarity and recollection (i.e., the two types of memory that support recognition) for objects, faces and scenes. We show that the mediodorsal thalamus (MDt) plays a material-general role in familiarity, while the anterior thalamus plays a material-general role in recollection. Material-specific regions were found for scene familiarity (ventral posteromedial and pulvinar thalamic nuclei) and face familiarity (left ventrolateral thalamus). Increased functional connectivity between the MDt and the parahippocampal (PHC) and perirhinal cortices (PRC) of the MTL underpinned increases in reported familiarity confidence. The extent of this connectivity reliably correlated with familiarity performance depending on the type of stimulus in memory. MDt-PRC connectivity correlated with object and face familiarity, while MDt-PHC connectivity correlated with scene familiarity. These findings suggest that familiarity signals are generated through the dynamic interaction of functionally connected MTL-thalamic structures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|