Mild musculoskeletal and locomotor alterations in adult rats with white matter injury following prenatal ischemia

Autor: Delcour, Maxime, Russier, Michael, Xin, Dong, Massicotte, Vicky, Barbe, Mary, Coq, Jacques-Olivier, Coq, Jacques‐olivier
Přispěvatelé: Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS - Inserm U1072), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2011
Předmět:
[SDV]Life Sciences [q-bio]
Physiology
MESH: Rats
Sprague-Dawley
Hindlimb
Nerve Fibers
Myelinated
MESH: Animals
Newborn
Rats
Sprague-Dawley
MESH: Pregnancy
Pregnancy
MESH: Animals
Treadmill
Gait
MESH: Muscle
Skeletal
MESH: Infant
Newborn
MESH: Posture
MESH: Motor Activity
MESH: Nerve Fibers
Myelinated
Astrogliosis
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Hypoxia-Ischemia
Brain
Female
Psychology
Infant
Premature
Locomotion
MESH: Infant
Premature
MESH: Cerebral Palsy
MESH: Rats
Posture
MESH: Locomotion
Ischemia
Motor Activity
MESH: Prenatal Exposure Delayed Effects
Cerebral palsy
White matter
Developmental Neuroscience
medicine
Animals
Humans
Muscle
Skeletal
MESH: Humans
Cerebral Palsy
MESH: Gait
Infant
Newborn
medicine.disease
Rats
Disease Models
Animal
Animals
Newborn
MESH: Hypoxia-Ischemia
Brain
MESH: Disease Models
Animal
Ankle
MESH: Female
Neuroscience
Developmental Biology
Zdroj: International Journal of Developmental Neuroscience
International Journal of Developmental Neuroscience, 2011, 29 (6), pp.593-607. ⟨10.1016/j.ijdevneu.2011.02.010⟩
ISSN: 1873-474X
0736-5748
DOI: 10.1016/j.ijdevneu.2011.02.010
Popis: Early brain injury including white matter damage (WMD) appears strongly correlated to perinatal hypoxia-ischemia and adverse neurological outcomes in preterm survivors. Indeed, WMD has been widely associated with subtle to major motor disturbances, sensory, behavioral and cognitive impairments in preterm infants who afterward develop cerebral palsy (CP). Prenatal ischemia (PI) has been shown to reproduce the main features of WMD observed in preterm infants. The present study was aimed at determining in adult rats the impact of PI on brain axons, musculoskeletal histology and locomotor activity. PI was induced by unilateral intrauterine artery ligation at E17 in pregnant rats. We found axonal degeneration and reactive astrogliosis in several white matter regions of adult PI rats. We found mild myopathic and secondary joint changes, including increased variability in myofiber size in several hind limb muscles, decreased myofibers numbers but increased Pax 7 cells and myofiber size in the gastrocnemius, and mild knee and ankle chondromalacia. Although treadmill locomotion appeared normal, several kinematic parameters, such as stride length, amplitude, velocity and leg joint angles were altered in adult PI rats compared to shams. Using intra- and inter-group variability of kinematic parameters, PI seemed to impair the maturation of locomotion on the treadmill. In addition, PI rats exhibited spontaneous hyperactivity in open-field test. Musculoskeletal changes appeared concomitant with mild impairments in gait and posture. Our rodent model of WMD based on PI reproduces the mild motor deficits and musculoskeletal changes observed in many preterm infants with a perinatal history of hypoxia-ischemia, and contributes towards a better understanding of the interplay between brain injury, musculoskeletal histopathology and gait disturbances encountered subsequently.
Databáze: OpenAIRE
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